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Dynamin 1 antibody (AA 698-851)

DNM1 Reactivity: Human, Mouse, Rat, Dog, Chicken WB, IHC, IF, IP Host: Mouse Monoclonal 41-Dynamin unconjugated
Catalog No. ABIN967852
  • Target See all Dynamin 1 (DNM1) Antibodies
    Dynamin 1 (DNM1)
    Binding Specificity
    • 30
    • 30
    • 15
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 698-851
    Reactivity
    • 104
    • 50
    • 47
    • 10
    • 8
    • 7
    • 3
    • 2
    • 2
    • 2
    • 1
    Human, Mouse, Rat, Dog, Chicken
    Host
    • 97
    • 9
    • 2
    Mouse
    Clonality
    • 106
    • 3
    Monoclonal
    Conjugate
    • 48
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This Dynamin 1 antibody is un-conjugated
    Application
    • 86
    • 39
    • 39
    • 34
    • 18
    • 14
    • 13
    • 5
    • 5
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
    Cross-Reactivity
    Human, Dog (Canine), Chicken, Mouse (Murine)
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Rat Dynamin I aa. 698-851
    Clone
    41-Dynamin
    Isotype
    IgG1
    Top Product
    Discover our top product DNM1 Primary Antibody
  • Comment

    Related Products: ABIN968539, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20° C.
  • Hayes, Chawla, Corvera: "TGF beta receptor internalization into EEA1-enriched early endosomes: role in signaling to Smad2." in: The Journal of cell biology, Vol. 158, Issue 7, pp. 1239-49, (2002) (PubMed).

    Kalthoff, Groos, Kohl, Mahrhold, Ungewickell: "Clint: a novel clathrin-binding ENTH-domain protein at the Golgi." in: Molecular biology of the cell, Vol. 13, Issue 11, pp. 4060-73, (2002) (PubMed).

    Schmidlin, Dery, DeFea, Slice, Patierno, Sternini, Grady, Bunnett: "Dynamin and Rab5a-dependent trafficking and signaling of the neurokinin 1 receptor." in: The Journal of biological chemistry, Vol. 276, Issue 27, pp. 25427-37, (2001) (PubMed).

    Ochoa, Slepnev, Neff, Ringstad, Takei, Daniell, Kim, Cao, McNiven, Baron, De Camilli: "A functional link between dynamin and the actin cytoskeleton at podosomes." in: The Journal of cell biology, Vol. 150, Issue 2, pp. 377-89, (2000) (PubMed).

    Scaife, Gout, Waterfield, Margolis: "Growth factor-induced binding of dynamin to signal transduction proteins involves sorting to distinct and separate proline-rich dynamin sequences." in: The EMBO journal, Vol. 13, Issue 11, pp. 2574-82, (1994) (PubMed).

  • Target
    Dynamin 1 (DNM1)
    Alternative Name
    Dynamin (DNM1 Products)
    Synonyms
    DNM antibody, Dnm antibody, AI838169 antibody, Ftfl antibody, mKIAA4093 antibody, dnm antibody, DNM1 antibody, Dnm1 antibody, dnm1 antibody, si:dkey-246l19.2 antibody, dynamin 1 antibody, dynamin-1 antibody, dynamin 1a antibody, DNM1 antibody, Dnm1 antibody, BACOIKO008_37 antibody, PTRG_07818 antibody, PTRG_08097 antibody, dnm1 antibody, LOC100168088 antibody, LOC100199205 antibody, dnm1a antibody
    Background
    Dynamin is a nerve terminal phosphoprotein with intrinsic GTPase activity which plays an important role in endocytosis. This GTPase activity is stimulated in vitro by microtubules, SH3 domain-containing proteins, phospholipids, and Protein Kinase C (PKC)-mediated phosphorylation. There are at least two distinct dynamin genes in mammals, which show 79% identity, encoding proteins Dynamin I and Dynamin II. Dynamin I is expressed almost exclusively in the central nervous system while Dynamin II expression is ubiquitous. Depolarization stimulates synaptic vesicle recycling and Dynamin I is subsequently dephosphorylated. This rapid dephosphorylation is mediated by calcineurin which acts as a switch for depolarization-initiated synaptic vesicle endocytosis. The C-terminus of dynamin contains two clusters of proline-rich SH3 domain binding proline motifs which interact with known SH3 domain proteins during tyrosine kinase receptor activation. It is reported that clone 41 detects both dynamin I and dynamin II.
    Molecular Weight
    100 kDa
    Pathways
    Toll-Like Receptors Cascades, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling
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