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CNTNAP1 antibody (AA 1-1513)

CNTNAP1 Reactivity: Human, Mouse, Rat, Dog, Chicken, Frog WB, IHC, IP, IF Host: Mouse Monoclonal 30-p190 unconjugated
Catalog No. ABIN967780
  • Target See all CNTNAP1 Antibodies
    CNTNAP1 (Contactin Associated Protein 1 (CNTNAP1))
    Binding Specificity
    • 16
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 1-1513
    Reactivity
    • 52
    • 22
    • 13
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Dog, Chicken, Frog
    Host
    • 50
    • 3
    • 2
    Mouse
    Clonality
    • 52
    • 3
    Monoclonal
    Conjugate
    • 19
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CNTNAP1 antibody is un-conjugated
    Application
    • 32
    • 17
    • 15
    • 13
    • 13
    • 11
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
    Cross-Reactivity
    Dog (Canine), Rat (Rattus), Mouse (Murine), Chicken, Frog
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human p190 aa. 1-1513
    Clone
    30-p190
    Isotype
    IgG1
    Top Product
    Discover our top product CNTNAP1 Primary Antibody
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20°C.
  • Maddox, Burridge: "RhoA is required for cortical retraction and rigidity during mitotic cell rounding." in: The Journal of cell biology, Vol. 160, Issue 2, pp. 255-65, (2003) (PubMed).

    Wolf, Draghi, Liang, Dai, Uhrbom, Eklöf, Westermark, Holland, Resh: "p190RhoGAP can act to inhibit PDGF-induced gliomas in mice: a putative tumor suppressor encoded on human chromosome 19q13.3." in: Genes & development, Vol. 17, Issue 4, pp. 476-87, (2003) (PubMed).

    Brandt, Gimona, Hillmann, Haller, Mischak: "Protein kinase C induces actin reorganization via a Src- and Rho-dependent pathway." in: The Journal of biological chemistry, Vol. 277, Issue 23, pp. 20903-10, (2002) (PubMed).

    Nakahara, Mueller, Nomizu, Yamada, Yeh, Chen: "Activation of beta1 integrin signaling stimulates tyrosine phosphorylation of p190RhoGAP and membrane-protrusive activities at invadopodia." in: The Journal of biological chemistry, Vol. 273, Issue 1, pp. 9-12, (1998) (PubMed).

    Settleman, Narasimhan, Foster, Weinberg: "Molecular cloning of cDNAs encoding the GAP-associated protein p190: implications for a signaling pathway from ras to the nucleus." in: Cell, Vol. 69, Issue 3, pp. 539-49, (1992) (PubMed).

  • Target
    CNTNAP1 (Contactin Associated Protein 1 (CNTNAP1))
    Alternative Name
    p190 (CNTNAP1 Products)
    Synonyms
    CNTNAP1 antibody, CASPR antibody, CNTNAP antibody, NRXN4 antibody, P190 antibody, Caspr antibody, AI841080 antibody, NCP1 antibody, Nrxn4 antibody, p190 antibody, shm antibody, contactin associated protein 1 antibody, contactin associated protein-like 1 antibody, CNTNAP1 antibody, cntnap1 antibody, Cntnap1 antibody
    Background
    GTPase activating proteins (GAPs) stimulate the GTP-hydrolyzing activity of GTPases, such as p21[ ras]. Ras-GAP (120kDa) is perhaps the best characterized GAP. p190 is a Ras-GAP associated protein that is tyrosine phosphorylated in transformed and growth factor-stimulated cells. Ras-GAP and p190 are targets of oncoproteins and growth factor receptors. Recombinant p190 enhances GTPase activity of the rho family of GTPases. The complete sequence of p190 exhibits three major regions: an N-terminal region with homology to all GTPases, a middle region homologous to transcriptional repressors, and a C-terminal region the is similar to n-chimerin and other small GTPases.
    Molecular Weight
    190 kDa
    Pathways
    Cell-Cell Junction Organization
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