TYK2 antibody

Catalog No. ABIN967218

Product Details anti-TYK2 Antibody

Target: TYK2 (Tyrosine Kinase 2 (TYK2))

Reactivity: Human

Host: Please inquire

Clonality: Monoclonal

Conjugate: This TYK2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: Ni-NTA purified truncated recombinant Tyk2 expressed in E. Coli strain BL21 (DE3)

Purification: Crude ascites.

Isotype: IgG1

Application Details

Application Notes: Western Blot: 1: 500- 1: 2,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: -20 °C

References for anti-TYK2 antibody (ABIN967218)

Shaw, Freeman, Scott, Fox, Bzik, Belkaid, Yap: "Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 12, pp. 7263-71, (2006) (PubMed).

Stoiber, Kovacic, Schuster, Schellack, Karaghiosoff, Kreibich, Weisz, Artwohl, Kleine, Muller, Baumgartner-Parzer, Ghysdael, Freissmuth, Sexl: "TYK2 is a key regulator of the surveillance of B lymphoid tumors." in: The Journal of clinical investigation, Vol. 114, Issue 11, pp. 1650-8, (2004) (PubMed).

Seto, Nakajima, Suto, Shimoda, Saito, Nakayama, Iwamoto: "Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 2, pp. 1077-83, (2003) (PubMed).

Target Details for TYK2

Target: TYK2 (Tyrosine Kinase 2 (TYK2))

Alternative Name: Tyk2 (TYK2 Products)

Synonyms: JTK1 antibody, tyrosine kinase 2 antibody, TYK2 antibody, Tyk2 antibody

Background: Tyk2 (tyrosine kinase 2),with 1187-amino acid protein (about 131kDa), belongs to the family of non-receptor janus tyrosine kinases, which also includes Jak1, Jak2, and Jak3. Kinases of the Jak family regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Tyk2 is activated by a variety of cytokines: IFN-alpha, IFN-beta, IL-6, IL-10, IL-12, and IL-13 and promotes IFN-gamma production by Th1-type CD4 cells. Tyk2 can be viewed as a dual-function Jak, mediating both pro-inflammatory and anti-inflammatory cytokine responses. Tyk2 is also an important regulator of lymphoid tumor surveillance.

Gene ID: 7297

Pathways: JAK-STAT Signaling, Hepatitis C