TDG antibody (C-Term)

Catalog No. ABIN967162

Product Details anti-TDG Antibody

Target: TDG (Thymine-DNA Glycosylase (TDG))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TDG antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human TDG (G/T mismatch-specific thymine DNA glycosylase)

Application Details

Restrictions: For Research Use only

Handling

Storage: 4 °C

References for anti-TDG antibody (ABIN967162)

Baba, Maita, Jee, Uchimura, Saitoh, Sugasawa, Hanaoka, Tochio, Hiroaki, Shirakawa: "Crystal structure of thymine DNA glycosylase conjugated to SUMO-1." in: Nature, Vol. 435, Issue 7044, pp. 979-82, (2005) (PubMed).

Hardeland, Steinacher, Jiricny, Schär: "Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover." in: The EMBO journal, Vol. 21, Issue 6, pp. 1456-64, (2002) (PubMed).

Neddermann, Gallinari, Lettieri, Schmid, Truong, Hsuan, Wiebauer, Jiricny: "Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase." in: The Journal of biological chemistry, Vol. 271, Issue 22, pp. 12767-74, (1996) (PubMed).

Neddermann, Jiricny: "Efficient removal of uracil from G.U mispairs by the mismatch-specific thymine DNA glycosylase from HeLa cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 5, pp. 1642-6, (1994) (PubMed).

Target Details for TDG

Target: TDG (Thymine-DNA Glycosylase (TDG))

Alternative Name: TDG (TDG Products)

Synonyms: 5-MCDG antibody, wu:fb44b11 antibody, zgc:110622 antibody, MGC82456 antibody, MGC89441 antibody, E130317C12Rik antibody, JZA-3 antibody, Jza1 antibody, hTDG antibody, thymine DNA glycosylase antibody, thymine DNA glycosylase, tandem duplicate 1 antibody, putative g/t mismatch-specific thymine DNA glycosylase antibody, G/T mismatch-specific thymine DNA glycosylase antibody, thymine DNA glycosylase S homeolog antibody, thymine-DNA glycosylase antibody, TDG antibody, tdg.1 antibody, Smp_149220 antibody, Tsp_05734 antibody, tdg.S antibody, tdg antibody, Tdg antibody

Background: In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. TDG(G/T mismatch-specific thymine DNA glycosylase) corrects G/T mispairs to G/C pairs. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, TDG can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. TDG can also remove uracil and 5-bromouracil from mispairs with guanine. Sumoylation on Lys-330 by either SUMO1 or SUMO2 induces dissociation of the product DNA. TDG belongs to the TDG/mug DNA glycosylase family.

Pathways: DNA Damage Repair, Chromatin Binding