SRA1 antibody

Catalog No. ABIN967076

Product Details anti-SRA1 Antibody

Target: SRA1 (Steroid Receptor RNA Activator 1 (SRA1))

Reactivity: Human

Host: Please inquire

Clonality: Monoclonal

Conjugate: This SRA1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificity: Ni-NTA purified truncated recombinant SRA expressed in E. Coli strain BL21 (DE3)

Purification: Crude ascites.

Isotype: IgG1

Application Details

Application Notes: Western Blot: 1: 500- 1: 2,000
IHC(P): 1: 500- 1: 2,000
IHC(F): 1: 500- 1: 2,000
ELISA: Propose dilution 1: 10,000 Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: -20 °C

References for anti-SRA1 antibody (ABIN967076)

Chooniedass-Kothari, Hamedani, Troup, Hubé, Leygue: "The steroid receptor RNA activator protein is expressed in breast tumor tissues." in: International journal of cancer. Journal international du cancer, Vol. 118, Issue 4, pp. 1054-9, (2006) (PubMed).

Chooniedass-Kothari, Emberley, Hamedani, Troup, Wang, Czosnek, Hube, Mutawe, Watson, Leygue: "The steroid receptor RNA activator is the first functional RNA encoding a protein." in: FEBS letters, Vol. 566, Issue 1-3, pp. 43-7, (2004) (PubMed).

Lanz, Chua, Barron, Söder, DeMayo, OMalley: "Steroid receptor RNA activator stimulates proliferation as well as apoptosis in vivo." in: Molecular and cellular biology, Vol. 23, Issue 20, pp. 7163-76, (2003) (PubMed).

Target Details for SRA1

Target: SRA1 (Steroid Receptor RNA Activator 1 (SRA1))

Alternative Name: SRA (SRA1 Products)

Synonyms: SRA antibody, SRAP antibody, STRAA1 antibody, pp7684 antibody, AA959952 antibody, Sra antibody, Srap antibody, Straa1 antibody, Strra1 antibody, zgc:86613 antibody, steroid receptor RNA activator 1 antibody, steroid receptor RNA activator 1 S homeolog antibody, cytoplasmic FMR1 interacting protein 1 antibody, SRA1 antibody, Sra1 antibody, sra1 antibody, sra1.S antibody, CYFIP1 antibody

Background: Steroid receptor RNA activator 1 (SRA), with 237-amino acid protein (about 27kDa), belongs to the growing family of functional non-coding RNAs. SRA was originally described as the first functional noncoding RNA able to specifically coactivate the activity of steroid receptors. Specifically, SRA exists as both an RNA transcript that forms a complex with steroid receptor coactivator-1 and as a stably expressed protein. Its expression is strongly up-regulated in many human tumors of the breast, uterus, and ovary, suggesting a potential role in pathogenesis. Although coactivation of steroid-dependent transcription by SRA is accompanied by a proliferative response, overexpression is not in itself sufficient to induce turmorigenesis.

Gene ID: 10011

Pathways: EGFR Signaling Pathway, Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development