OGG1 antibody (acLys338, acLys341, C-Term)

Catalog No. ABIN966716

Product Details anti-OGG1 Antibody

Target: OGG1 (8-Oxoguanine DNA Glycosylase (OGG1))

Binding Specificity: acLys338, acLys341, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OGG1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human OGG1 (N-glycosylase/DNA lyase)

Application Details

Restrictions: For Research Use only

Handling

Storage: 4 °C

References for anti-OGG1 antibody (ABIN966716)

Aburatani, Hippo, Ishida, Takashima, Matsuba, Kodama, Takao, Yasui, Yamamoto, Asano: "Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue." in: Cancer research, Vol. 57, Issue 11, pp. 2151-6, (1997) (PubMed).

Rosenquist, Zharkov, Grollman: "Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 14, pp. 7429-34, (1997) (PubMed).

Roldán-Arjona, Wei, Carter, Klungland, Anselmino, Wang, Augustus, Lindahl: "Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 15, pp. 8016-20, (1997) (PubMed).

Kuo, Sklar: "Augmented expression of a human gene for 8-oxoguanine DNA glycosylase (MutM) in B lymphocytes of the dark zone in lymph node germinal centers." in: The Journal of experimental medicine, Vol. 186, Issue 9, pp. 1547-56, (1997) (PubMed).

Bjorâs, Luna, Johnsen, Hoff, Haug, Rognes, Seeberg: "Opposite base-dependent reactions of a human base excision repair enzyme on DNA containing 7,8-dihydro-8-oxoguanine and abasic sites." in: The EMBO journal, Vol. 16, Issue 20, pp. 6314-22, (1997) (PubMed).

Target Details for OGG1

Target: OGG1 (8-Oxoguanine DNA Glycosylase (OGG1))

Alternative Name: OGG1 (OGG1 Products)

Synonyms: OGG1 antibody, zgc:158858 antibody, 8-oxoguanine-DNA glycosylase 1 antibody, ARABIDOPSIS 8-OXOGUANINE-DNA GLYCOSYLASE 1 antibody, ATOGG1 antibody, F8K7.14 antibody, F8K7_14 antibody, 19.m02329 antibody, DDBDRAFT_0184479 antibody, DDBDRAFT_0233024 antibody, DDB_0184479 antibody, DDB_0233024 antibody, ogg1 antibody, Tb04.1H19.930 antibody, HMMH antibody, HOGG1 antibody, MUTM antibody, OGH1 antibody, Mmh antibody, 8-oxoguanine DNA glycosylase antibody, 8-oxoguanine DNA glycosylase L homeolog antibody, 8-oxoguanine-DNA glycosylase 1 antibody, 8-OXOGUANINE DNA GLYCOSYLASE antibody, putative 8-oxoguanine DNA glycosylase antibody, 8-oxoguanine DNA-glycosylase antibody, N-glycosylase/DNA lyase OGG1 antibody, 8-oxoguanine DNA-glycosylase 1 antibody, OGG1 antibody, ogg1.L antibody, ogg1 antibody, ECU08_0770 antibody, CA_C2707 antibody, BBOV_I004290 antibody, Smp_074010.1 antibody, LOC9329243 antibody, Tb927.4.2480 antibody, Ogg1 antibody

Background: DNA repair enzyme that incises DNA at 8-oxoG residues. OGG1 (N-glycosylase/DNA lyase) excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-Nmethylformamidopyrimidine (FAPY) from damaged DNA. OGG1 has a beta-lyase activity that nicks DNA 3' to the lesion. Defects in OGG1 are associated with tumor formation.Defects in OGG1 are a cause of renal cell carcinoma OGG1 belongs to the type-1 OGG1 family.
Synonyms: MMH, MUTM, OGH1

Pathways: DNA Damage Repair