MAPK7 antibody (C-Term, Isoform 1)

Catalog No. ABIN966526

Product Details anti-MAPK7 Antibody

Target: MAPK7 (Mitogen-Activated Protein Kinase 7 (MAPK7))

Binding Specificity: C-Term, Isoform 1

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAPK7 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human MAPK7 (mitogen-activated protein kinase 7 isoform 1)

Application Details

Restrictions: For Research Use only

Handling

Storage: 4 °C

References for anti-MAPK7 antibody (ABIN966526)

Sawhney, Liu, Brattain: "A novel role of ERK5 in integrin-mediated cell adhesion and motility in cancer cells via Fak signaling." in: Journal of cellular physiology, Vol. 219, Issue 1, pp. 152-61, (2009) (PubMed).

Zhao, Geng, Ge, Wang, Zhang, Kang: "Activation of ERK5 in angiotensin II-induced hypertrophy of human aortic smooth muscle cells." in: Molecular and cellular biochemistry, Vol. 322, Issue 1-2, pp. 171-8, (2009) (PubMed).

Montero, Ocaña, Abad, Ortiz-Ruiz, Pandiella, Esparís-Ogando: "Expression of Erk5 in early stage breast cancer and association with disease free survival identifies this kinase as a potential therapeutic target." in: PLoS ONE, Vol. 4, Issue 5, pp. e5565, (2009) (PubMed).

Zen, Yasui, Nakajima, Zen, Zen, Gen, Mitsuyoshi, Minami, Mitsufuji, Tanaka, Itoh, Nakanuma, Taniwaki, Arii, Okanoue, Yoshikawa: "ERK5 is a target for gene amplification at 17p11 and promotes cell growth in hepatocellular carcinoma by regulating mitotic entry." in: Genes, chromosomes & cancer, Vol. 48, Issue 2, pp. 109-20, (2008) (PubMed).

Arnoux, Nassour, LHelgoualch, Hipskind, Savagner: "Erk5 controls Slug expression and keratinocyte activation during wound healing." in: Molecular biology of the cell, Vol. 19, Issue 11, pp. 4738-49, (2008) (PubMed).

Buschbeck, Eickhoff, Sommer, Ullrich: "Phosphotyrosine-specific phosphatase PTP-SL regulates the ERK5 signaling pathway." in: The Journal of biological chemistry, Vol. 277, Issue 33, pp. 29503-9, (2002) (PubMed).

Esparís-Ogando, Díaz-Rodríguez, Montero, Yuste, Crespo, Pandiella: "Erk5 participates in neuregulin signal transduction and is constitutively active in breast cancer cells overexpressing ErbB2." in: Molecular and cellular biology, Vol. 22, Issue 1, pp. 270-85, (2001) (PubMed).

Purandare, Lee, Patel: "Assignment of big MAP kinase (PRKM7) to human chromosome 17 band p11.2 with somatic cell hybrids." in: Cytogenetics and cell genetics, Vol. 83, Issue 3-4, pp. 258-9, (1999) (PubMed).

Kato, Tapping, Huang, Watson, Ulevitch, Lee: "Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor." in: Nature, Vol. 395, Issue 6703, pp. 713-6, (1998) (PubMed).

English, Pearson, Baer, Cobb: "Identification of substrates and regulators of the mitogen-activated protein kinase ERK5 using chimeric protein kinases." in: The Journal of biological chemistry, Vol. 273, Issue 7, pp. 3854-60, (1998) (PubMed).

Target Details for MAPK7

Target: MAPK7 (Mitogen-Activated Protein Kinase 7 (MAPK7))

Alternative Name: MAPK7 (MAPK7 Products)

Synonyms: BMK1 antibody, ERK4 antibody, ERK5 antibody, PRKM7 antibody, Erk5-T antibody, ATMPK7 antibody, F8D23.5 antibody, F8D23_5 antibody, MAP kinase 7 antibody, Bmk1 antibody, Erk5 antibody, Prkm7 antibody, ERK-5 antibody, bmk1 antibody, erk4 antibody, mapk7 antibody, prkm7 antibody, mitogen-activated protein kinase 7 antibody, MAP kinase 7 antibody, mitogen-activated protein kinase 7 L homeolog antibody, MAPK7 antibody, Mapk7 antibody, MPK7 antibody, mapk7.L antibody

Background: MAPK7 (mitogen-activated protein kinase 7 isoform 1) is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported.
Synonyms: BMK1, ERK4, ERK5, PRKM7

Pathways: MAPK Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, cAMP Metabolic Process, Toll-Like Receptors Cascades, Negative Regulation of intrinsic apoptotic Signaling