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L3MBTL1 antibody (N-Term)

L3MBTL1 Reactivity: Human IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN966472
  • Target See all L3MBTL1 Antibodies
    L3MBTL1 (L(3)mbt-Like 1 (L3MBTL1))
    Binding Specificity
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 18
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    Human
    Host
    • 17
    • 2
    • 1
    Rabbit
    Clonality
    • 18
    • 1
    • 1
    Polyclonal
    Conjugate
    • 19
    • 1
    This L3MBTL1 antibody is un-conjugated
    Application
    • 15
    • 7
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Immunohistochemistry (IHC)
    Immunogen
    Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human L3MBTL(Lethal(3)malignant brain tumor-like protein )
    Top Product
    Discover our top product L3MBTL1 Primary Antibody
  • Restrictions
    For Research Use only
  • Storage
    4 °C
  • Boccuni, MacGrogan, Scandura, Nimer: "The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6)." in: The Journal of biological chemistry, Vol. 278, Issue 17, pp. 15412-20, (2003) (PubMed).

    Wang, Tereshko, Boccuni, MacGrogan, Nimer, Patel: "Malignant brain tumor repeats: a three-leaved propeller architecture with ligand/peptide binding pockets." in: Structure (London, England : 1993), Vol. 11, Issue 7, pp. 775-89, (2003) (PubMed).

    Koga, Matsui, Hirota, Takebayashi, Okumura, Saya: "A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes." in: Oncogene, Vol. 18, Issue 26, pp. 3799-809, (1999) (PubMed).

  • Target
    L3MBTL1 (L(3)mbt-Like 1 (L3MBTL1))
    Alternative Name
    L3MBTL (L3MBTL1 Products)
    Synonyms
    C630004G01 antibody, L3mbtl antibody, mKIAA0681 antibody, H-L(3)MBT antibody, L3MBTL antibody, ZC2HC3 antibody, dJ138B7.3 antibody, RGD1307316 antibody, l(3)mbt-like (Drosophila) antibody, L3MBTL1, histone methyl-lysine binding protein antibody, l(3)mbt-like 1 (Drosophila) antibody, L3mbtl1 antibody, L3MBTL1 antibody
    Background
    L3MBTL(Lethal(3)malignant brain tumor-like protein ) is polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. L3MBTL participates in the ETV6-mediated repression. L3MBTL probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis. L3MBTL interacts with ETV6 and is widely expressed. Expression is reduced in colorectal cancer cell line SW480 and promyelocytic leukemia cell line HL-60. In interphase cells, it is scattered throughout the nucleoplasm. In mitotic cells, it strongly associates with condensed chromosomes from the prophase to telophase.
    Synonyms: KIAA0681, L3MBT, L3MBTL1
    Pathways
    Chromatin Binding
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