L3MBTL1 antibody (N-Term)

Catalog No. ABIN966472

Product Details anti-L3MBTL1 Antibody

Target: L3MBTL1 (L(3)mbt-Like 1 (L3MBTL1))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This L3MBTL1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human L3MBTL(Lethal(3)malignant brain tumor-like protein )

Application Details

Restrictions: For Research Use only

Handling

Storage: 4 °C

References for anti-L3MBTL1 antibody (ABIN966472)

Boccuni, MacGrogan, Scandura, Nimer: "The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6)." in: The Journal of biological chemistry, Vol. 278, Issue 17, pp. 15412-20, (2003) (PubMed).

Wang, Tereshko, Boccuni, MacGrogan, Nimer, Patel: "Malignant brain tumor repeats: a three-leaved propeller architecture with ligand/peptide binding pockets." in: Structure (London, England : 1993), Vol. 11, Issue 7, pp. 775-89, (2003) (PubMed).

Koga, Matsui, Hirota, Takebayashi, Okumura, Saya: "A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes." in: Oncogene, Vol. 18, Issue 26, pp. 3799-809, (1999) (PubMed).

Target Details for L3MBTL1

Target: L3MBTL1 (L(3)mbt-Like 1 (L3MBTL1))

Alternative Name: L3MBTL (L3MBTL1 Products)

Synonyms: C630004G01 antibody, L3mbtl antibody, mKIAA0681 antibody, H-L(3)MBT antibody, L3MBTL antibody, ZC2HC3 antibody, dJ138B7.3 antibody, RGD1307316 antibody, l(3)mbt-like (Drosophila) antibody, L3MBTL1, histone methyl-lysine binding protein antibody, l(3)mbt-like 1 (Drosophila) antibody, L3mbtl1 antibody, L3MBTL1 antibody

Background: L3MBTL(Lethal(3)malignant brain tumor-like protein ) is polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. L3MBTL participates in the ETV6-mediated repression. L3MBTL probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis. L3MBTL interacts with ETV6 and is widely expressed. Expression is reduced in colorectal cancer cell line SW480 and promyelocytic leukemia cell line HL-60. In interphase cells, it is scattered throughout the nucleoplasm. In mitotic cells, it strongly associates with condensed chromosomes from the prophase to telophase.
Synonyms: KIAA0681, L3MBT, L3MBTL1

Pathways: Chromatin Binding