JAK2 antibody (AA 745-955)
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- Target See all JAK2 Antibodies
- JAK2 (Janus Kinase 2 (JAK2))
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Binding Specificity
- AA 745-955
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This JAK2 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Purification
- Ascitic fluid
- Immunogen
- Purified recombinant fragment of JAK2(745-955aa) expressed in E. Coli.
- Clone
- 1C1
- Isotype
- IgG1
- Top Product
- Discover our top product JAK2 Primary Antibody
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- Application Notes
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Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test. - Restrictions
- For Research Use only
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- Format
- Liquid
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
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Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 12, pp. 6651-8, (2000) (PubMed).
: "The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity." in: The Journal of biological chemistry, Vol. 274, Issue 44, pp. 31531-42, (1999) (PubMed).
: "Plasma levels of lipid and cholesterol oxidation products and cytokines in diabetes mellitus and cigarette smoking: effects of vitamin E treatment." in: Atherosclerosis, Vol. 129, Issue 2, pp. 169-76, (1997) (PubMed).
: "
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Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 12, pp. 6651-8, (2000) (PubMed).
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- Target
- JAK2 (Janus Kinase 2 (JAK2))
- Alternative Name
- JAK2 (JAK2 Products)
- Synonyms
- JAK2bCA antibody, jak2 antibody, JTK10 antibody, THCYT3 antibody, AI504024 antibody, C81284 antibody, Fd17 antibody, JAK-2 antibody, Janus kinase 2b antibody, Janus kinase 2 antibody, jak2b antibody, JAK2 antibody, Jak2 antibody
- Background
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This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
Synonyms: JTK10, JAK2 - Molecular Weight
- 130.6kDa
- Gene ID
- 3717
- Pathways
- JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Response to Growth Hormone Stimulus, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling, Unfolded Protein Response
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