MLL/KMT2A antibody (N-Term)

Catalog No. ABIN966301

Product Details anti-MLL/KMT2A Antibody

Target: MLL/KMT2A (MLL) (Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MLL/KMT2A antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to near N-terminal residues of human HRX (Histone-lysine N-methyltransferase HRX)

Application Details

Restrictions: For Research Use only

Handling

Storage: 4 °C

References for anti-MLL/KMT2A antibody (ABIN966301)

Nilson, Löchner, Siegler, Greil, Beck, Fey, Marschalek: "Exon/intron structure of the human ALL-1 (MLL) gene involved in translocations to chromosomal region 11q23 and acute leukaemias." in: British journal of haematology, Vol. 93, Issue 4, pp. 966-72, (1996) (PubMed).

Mbangkollo, Burnett, McCabe, Thirman, Gill, Yu, Rowley, Diaz: "The human MLL gene: nucleotide sequence, homology to the Drosophila trx zinc-finger domain, and alternative splicing." in: DNA and cell biology, Vol. 14, Issue 6, pp. 475-83, (1995) (PubMed).

Gu, Alder, Nakamura, Schichman, Prasad, Canaani, Saito, Croce, Canaani: "Sequence analysis of the breakpoint cluster region in the ALL-1 gene involved in acute leukemia." in: Cancer research, Vol. 54, Issue 9, pp. 2327-30, (1994) (PubMed).

Yamamoto, Seto, Komatsu, Iida, Akao, Kojima, Kodera, Nakazawa, Ariyoshi, Takahashi: "Two distinct portions of LTG19/ENL at 19p13 are involved in t(11;19) leukemia." in: Oncogene, Vol. 8, Issue 10, pp. 2617-25, (1993) (PubMed).

Tkachuk, Kohler, Cleary: "Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias." in: Cell, Vol. 71, Issue 4, pp. 691-700, (1992) (PubMed).

Gu, Nakamura, Alder, Prasad, Canaani, Cimino, Croce, Canaani: "The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene." in: Cell, Vol. 71, Issue 4, pp. 701-8, (1992) (PubMed).

Howell, Rao: "Cloning a replication function from the streptomycete bacteriophage FP43." in: Gene, Vol. 113, Issue 1, pp. 113-7, (1992) (PubMed).

Target Details for MLL/KMT2A

Target: MLL/KMT2A (MLL) (Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))

Alternative Name: HRX (MLL Products)

Synonyms: ALL-1 antibody, CXXC7 antibody, HRX antibody, HTRX1 antibody, MLL antibody, MLL/GAS7 antibody, MLL1A antibody, TET1-MLL antibody, TRX1 antibody, WDSTS antibody, 6430520K01 antibody, All1 antibody, Cxxc7 antibody, Mll antibody, Mll1 antibody, mKIAA4050 antibody, lysine methyltransferase 2A antibody, lysine (K)-specific methyltransferase 2A antibody, KMT2A antibody, Kmt2a antibody

Background: HRX (Histone-lysine N-methyltransferase HRX) functions as histone methyltransferase. HRX methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. HRX promotes PPP1R15A-induced apoptosis. HRX interacts with SBF1 and PPP1R15A. HRX is a component of the MLL complex, at least composed of MLL, ASH2L, RBBP5, DPY30, WDR5, MEN1,HCFC1 and HCFC2. Chromosomal aberrations involving MLL are a cause of acute leukemias. A chromosomal aberration involving MLL may be a cause of chronic neutrophilic leukemia. HRX belongs to the histone-lysine methyltransferase family and TRX/MLL subfamily.
Synonyms: ALL1, CXXC7(CXXC-type zinc finger protein 7), HTRX, KMT2A, TRX1, MLL, Zinc finger protein HRX, Trithorax-like protein, Lysine N-methyltransferase 2A

Pathways: Warburg Effect