Rabbit IgG polyclonal antibody for FAS-associated factor 1 ( FAF1) detection. Tested with WB in Human, Mouse, Rat.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminal of human FAF1, identical to the related mouse and rat sequences.< br/>Immunogen was affinity purified.
At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
Park, Jang, Lee, Lee, Kim: "Fas-associated factor-1 inhibits nuclear factor-kappaB (NF-kappaB) activity by interfering with nuclear translocation of the RelA (p65) subunit of NF-kappaB." in: The Journal of biological chemistry, Vol. 279, Issue 4, pp. 2544-9, (2004) (PubMed).
Ryu, Chae, Lee, Kim: "Identification and characterization of human Fas associated factor 1, hFAF1." in: Biochemical and biophysical research communications, Vol. 262, Issue 2, pp. 388-94, (1999) (PubMed).
Fas-associated factor-1 (FAF1) is a Fas-binding pro-apoptotic protein that is a component of the death-inducing signaling complex in Fas-mediated apoptosis. FAF1 is involved in negative regulation of NF-kappaB activation. In addition to the previously known function as a component of the Fas death-inducing signaling complex, i. e. NF-kappaB activity suppressor by cytoplasmic retention of NF-kappaB p65 via physical interaction. hFAF1 was expressed abundantly in testis, skeletal muscle, and heart as 2. 8 kb mRNA. Polyclonal antibody against hFAF1 detected 74 kD protein, a deduced protein size from the ORF and 40 kD protein in some cell lines.