EDEM1 antibody (C-Term)

Catalog No. ABIN966027

Product Details anti-EDEM1 Antibody

Target: EDEM1 (ER Degradation Enhancer, Mannosidase alpha-Like 1 (EDEM1))

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EDEM1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Purification: Purified by antigen-specific affinity chromatography.

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human EDEM1(ER degradation-enhancing alpha-mannosidase-like 1)

Application Details

Application Notes: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-EDEM1 antibody (ABIN966027)

Molinari, Calanca, Galli, Lucca, Paganetti: "Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle." in: Science (New York, N.Y.), Vol. 299, Issue 5611, pp. 1397-400, (2003) (PubMed).

Nagase, Seki, Ishikawa, Ohira, Kawarabayasi, Ohara, Tanaka, Kotani, Miyajima, Nomura: "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 3, Issue 5, pp. 321-9, 341-54, (1997) (PubMed).

Target Details for EDEM1

Target: EDEM1 (ER Degradation Enhancer, Mannosidase alpha-Like 1 (EDEM1))

Alternative Name: EDEM1 (EDEM1 Products)

Synonyms: zgc:55816 antibody, edem antibody, EDEM1 antibody, EDEM antibody, A130059K23Rik antibody, mKIAA0212 antibody, RGD1563633 antibody, ER degradation enhancer, mannosidase alpha-like 1 antibody, ER degradation enhancing alpha-mannosidase like protein 1 antibody, ER degradation-enhancing alpha-mannosidase-like protein 1 antibody, ER degradation enhancing alpha-mannosidase like protein 1 L homeolog antibody, edem1 antibody, EDEM1 antibody, LOC100637820 antibody, edem1.L antibody, Edem1 antibody

Background: EDEM1(ER degradation-enhancing alpha-mannosidase-like 1) extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. It lacks mannosidase activity. EDEM1 is located in endoplasmic reticulum membrane and is a single-pass type II membrane protein. EDEM1 belongs to the glycosyl hydrolase 47 family.

Pathways: ER-Nucleus Signaling