CD20 antibody

Catalog No. ABIN965776

Product Details anti-CD20 Antibody

Target: CD20 (MS4A1) (Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD20 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA

Purification: Ascitic fluid

Immunogen: Synthetic peptide corresponding to aa (EPANPSEKNSPSTQY) of human CD20,conjugated to KLH.

Clone: 3E9D3C1G3

Isotype: IgG

Application Details

Application Notes: Immunohistochemistry: 1/200 - 1/1000.
Immunofluorescence: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Handling

Format: Liquid

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

References for anti-CD20 antibody (ABIN965776)

Riley, Byar: "The rationale for and background of radioimmunotherapy: an emerging therapy for B-cell non-Hodgkin's lymphoma." in: Seminars in oncology nursing, Vol. 20, Issue 1 Suppl 1, pp. 1-7, (2004) (PubMed).

Reiners, Hansen, Krüssmann, Schön, Csernok, Gross, Engert, Von Strandmann: "Selective killing of B-cell hybridomas targeting proteinase 3, Wegener's autoantigen." in: Immunology, Vol. 112, Issue 2, pp. 228-36, (2004) (PubMed).

Byar: "Educating patients about radioimmunotherapy with yttrium 90 ibritumomab tiuxetan (Zevalin)." in: Seminars in oncology nursing, Vol. 20, Issue 1 Suppl 1, pp. 20-5, (2004) (PubMed).

Target Details for CD20

Target: CD20 (MS4A1) (Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1))

Alternative Name: CD20 (MS4A1 Products)

Synonyms: B1 antibody, Bp35 antibody, CD20 antibody, CVID5 antibody, LEU-16 antibody, MS4A2 antibody, S7 antibody, AA960661 antibody, Cd20 antibody, Ly-44 antibody, Ms4a2 antibody, MS4A1 antibody, bp35 antibody, cd20 antibody, ms4a2 antibody, leu-16 antibody, ms4a4c antibody, cd20-like antibody, membrane spanning 4-domains A1 antibody, membrane-spanning 4-domains, subfamily A, member 1 antibody, B-lymphocyte antigen CD20 antibody, MS4A1 antibody, Ms4a1 antibody, ms4a1 antibody, LOC101694281 antibody

Background: CD20 (MS4A1, membrane-spanning 4-domains, subfamily A, member 1) is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The CD20 antigen is present on human pre B lymphocytes and on B lymphocytes at all stages of maturation, except on plasma cells. Low level expression of the CD20 antigen has been detected on normal T lymphocytes. The CD20 molecule is involved in regulation of B cell differentiation, presumably via its reported function as a Ca++ channel subunit. And it is known to accelerate the G0 to G1 progression induced by IGF-1.
Synonyms: B1, S7, Bp35, CD20, MS4A2, LEU-16, MGC3969, MS4A1

Gene ID: 931