ABI1 antibody (C-Term)

Catalog No. ABIN965496

Product Details anti-ABI1 Antibody

Target: ABI1 (Abl-Interactor 1 (ABI1))

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABI1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Purification: Purified by antigen-specific affinity chromatography.

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human ABI1 (Abl-interactor 1)

Application Details

Application Notes: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-ABI1 antibody (ABIN965496)

Yamamoto, Suzuki, Sakaki: "Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease." in: Gene, Vol. 271, Issue 2, pp. 159-69, (2001) (PubMed).

Fan, Goff: "Abl interactor 1 binds to sos and inhibits epidermal growth factor- and v-Abl-induced activation of extracellular signal-regulated kinases." in: Molecular and cellular biology, Vol. 20, Issue 20, pp. 7591-601, (2000) (PubMed).

Ziemnicka-Kotula, Xu, Gu, Potempska, Kim, Jenkins, Trenkner, Kotula: "Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton." in: The Journal of biological chemistry, Vol. 273, Issue 22, pp. 13681-92, (1998) (PubMed).

Taki, Shibuya, Taniwaki, Hanada, Morishita, Bessho, Yanagisawa, Hayashi: "ABI-1, a human homolog to mouse Abl-interactor 1, fuses the MLL gene in acute myeloid leukemia with t(10;11)(p11.2;q23)." in: Blood, Vol. 92, Issue 4, pp. 1125-30, (1998) (PubMed).

Biesova, Piccoli, Wong: "Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth." in: Oncogene, Vol. 14, Issue 2, pp. 233-41, (1997) (PubMed).

Target Details for ABI1

Target: ABI1 (Abl-Interactor 1 (ABI1))

Alternative Name: ABI1 (ABI1 Products)

Synonyms: ABI-1 antibody, ABLBP4 antibody, E3B1 antibody, NAP1BP antibody, SSH3BP antibody, SSH3BP1 antibody, NAP1 antibody, Ssh3bp1 antibody, E3b1 antibody, abi1 antibody, wu:fc66g09 antibody, wu:fk56a10 antibody, zgc:73174 antibody, MGC84356 antibody, ABI1 antibody, abi-1 antibody, e3b1 antibody, nap1bp antibody, ssh3bp antibody, ssh3bp1 antibody, wu:fe48a10 antibody, zgc:153534 antibody, DKFZp469P1319 antibody, abl interactor 1 antibody, abl-interactor 1 antibody, abl-interactor 1a antibody, abl interactor 1 S homeolog antibody, abl-interactor 1b antibody, Abl-interactor 1 antibody, Abl interactor 1 antibody, ABI1 antibody, Abi1 antibody, abi1a antibody, abi1.S antibody, abi1 antibody, abi1b antibody, Bm1_44660 antibody, LOAG_04356 antibody

Background: The ABI1 (Abl-interactor 1) may act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/ or ABL2. The ABI1 may play a role in regulation of EGF-induced Erk pathway activation. It is involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 It participates in transduction of signals from Ras to Rac.

Pathways: RTK Signaling, Response to Water Deprivation, ER-Nucleus Signaling