WDR48 antibody (C-Term)

Catalog No. ABIN955556

Product Details anti-WDR48 Antibody

Target: WDR48 (WD Repeat Domain 48 (WDR48))

Binding Specificity: AA 610-638, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WDR48 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody detects WDR48 / p80 (C-term).

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Protein A column followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 610-638 amino acids from the C-terminal region of human WDR48

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.

Target Details for WDR48

Target: WDR48 (WD Repeat Domain 48 (WDR48))

Alternative Name: WDR48 / p80 (WDR48 Products)

Synonyms: P80 antibody, UAF1 antibody, 8430408H12Rik antibody, mKIAA1449 antibody, WD repeat domain 48 antibody, WDR48 antibody, Wdr48 antibody

Background: Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 by enhancing the USP1-mediated deubiquitination of FANCD2, USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12 and USP46, respectively. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP. In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1.Synonyms: KIAA1449, UAF1, USP1-associated factor 1, WD repeat endosomal protein, WD repeat-containing protein 48

Gene ID: 57599

NCBI Accession: NP_065890