TPSD1 antibody (C-Term)

Catalog No. ABIN955305

Product Details anti-TPSD1 Antibody

Target: TPSD1 (Tryptase delta 1 (TPSD1))

Binding Specificity: AA 171-201, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TPSD1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody detects TPSD1 (C-term).

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Protein A column followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 171-201 amino acids from the C-terminal region of human TPSD1

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.

Target Details for TPSD1

Target: TPSD1 (Tryptase delta 1 (TPSD1))

Alternative Name: TPSD1 (TPSD1 Products)

Synonyms: Tpsd1 antibody, MCP7-LIKE antibody, MCP7L1 antibody, MMCP-7L antibody, tryptase delta 1 antibody, protease, serine, 29 antibody, TPSD1 antibody, Prss29 antibody

Background: Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. Although this gene may be an exception, most of the tryptase genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. TPSD1 was once considered to be a pseudogene, although it is now believed to be a functional gene that encodes a protein.Synonyms: Tryptase delta

Gene ID: 23430

NCBI Accession: NP_036349