Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Reconstitution
Centrifuge vial prior to opening. Restore in sterile water to a concentration of 0.1-1.0 mg/mL.
Buffer
PBS, pH 7.2
Storage
4 °C/-20 °C
Storage Comment
The lyophilized antibody is stable at RT for up to 1 month. The reconstituted antibody is stable for at least two weeks at 2-8 °C. Frozen aliquots are stable for at least 6 months when stored at -20 °C. Avoid repeated freeze-thaw cycles!
Expiry Date
6 months
Target
TIE1
(tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 (TIE1))
JTK14 antibody, TIE antibody, D430008P04Rik antibody, tie-1 antibody, tyrosine kinase with immunoglobulin like and EGF like domains 1 antibody, tyrosine kinase with immunoglobulin-like and EGF-like domains 1 antibody, tyrosine-protein kinase receptor Tie-1 antibody, endothelium-specific receptor tyrosine kinase 1 antibody, TIE1 antibody, Tie1 antibody, CpipJ_CPIJ018933 antibody, tie1 antibody
Background
TIE-1 (tyrosine kinase with Ig and EGF homology domains 1) and TIE-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis.Synonyms: TIE, Tie-1, Tyrosine-protein kinase receptor Tie-1