STK38 antibody (AA 365-466)

Catalog No. ABIN954986

Product Details anti-STK38 Antibody

Target: STK38 (serine/threonine Kinase 38 (STK38))

Binding Specificity: AA 365-466

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This STK38 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: Recognizes STK38

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Protein A Chromatography

Immunogen: STK38 (AAH12085, 365 a.a. ~ 466 a.a) partial recombinant protein with GST tag.

Clone: 6F1

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.2

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C.

Target Details for STK38

Target: STK38 (serine/threonine Kinase 38 (STK38))

Alternative Name: STK38 (STK38 Products)

Synonyms: NDR antibody, NDR1 antibody, 5830476G13Rik antibody, 9530097A09Rik antibody, AA617404 antibody, Ndr1 antibody, trc antibody, si:ch1073-272h17.2 antibody, wu:fj80h03 antibody, zgc:55572 antibody, serine/threonine kinase 38 antibody, serine/threonine kinase 38 S homeolog antibody, serine/threonine kinase 38b antibody, serine/threonine kinase 38a antibody, STK38 antibody, Stk38 antibody, stk38.S antibody, stk38b antibody, stk38a antibody

Background: STK38 contains 1 protein kinase domain that interacts with mob1 and mob2.The homodimeric s100b binds to two molecules of stk38. It is ubiquitously expressed with highest levels observed in peripheral blood leukocytes. Stk38 activated by binding of s100b which releases autoinhibitory n-lobe interactions, enabling atp to bind and the autophosphorylation of ser-281. thr-444 then undergoes calcium- dependent phosphorylation by an upstream kinase. Interactions between phosphorylated thr-444 and the n-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of mob1/mobkl1a and mob2/hcca2 to the n-terminal of stk38.Synonyms: NDR1, Nuclear Dbf2-related kinase 1, Serine/threonine-protein kinase 38

Gene ID: 11329

NCBI Accession: NP_009202

UniProt: Q15208