SAR1B antibody (Middle Region)

Catalog No. ABIN954670

Product Details anti-SAR1B Antibody

Target: SAR1B (SAR1 Homolog B (SAR1B))

Binding Specificity: AA 96-124, Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SAR1B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: Recognizes SAR1B (Center).

Purification: Protein A column followed by peptide Affinity purification

Immunogen: KLH conjugated synthetic peptide between 96-124 amino acids from the Central region of Human SAR1B Genename: SAR1B

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for SAR1B

Target: SAR1B (SAR1 Homolog B (SAR1B))

Alternative Name: SAR1B (SAR1B Products)

Synonyms: SAR1 antibody, SAR1B antibody, SARA2 antibody, 2310075M17Rik antibody, 2900019I22Rik antibody, CMRD antibody, Sara1b antibody, Sara2 antibody, Sarb antibody, cmrd antibody, gtbpb antibody, sar1a antibody, sara2 antibody, SARA1B antibody, ANDD antibody, GTBPB antibody, zgc:73204 antibody, secretion associated Ras related GTPase 1B antibody, hypothetical protein antibody, SAR1 homolog B (S. cerevisiae) antibody, secretion associated, Ras related GTPase 1B L homeolog antibody, secretion associated, Ras related GTPase 1B antibody, SAR1B antibody, Sar1B antibody, sar1b antibody, Sar1b antibody, sar1b.L antibody

Background: SAR1B belongs to the small GTPase superfamily, SAR1 family. It is involved in transport from the endoplasmic reticulum to the Golgi apparatus and is activated by the guanine nucleotide exchange factor PREB. SAR1B is involved in the selection of the protein cargo and the assembly of the COPII coat complex. Defects in SAR1B are the cause of chylomicron retention disease (CMRD). CMRD is an autosomal recessive disorder of severe fat malabsorption associated with failure to thrive in infancy. The conditions are characterized by deficiency of fat-soluble vitamins, low blood cholesterol levels, and a selective absence of chylomicrons from blood. Affected individuals accumulate chylomicron-like particles in membrane-bound compartments of enterocytes, which contain large cytosolic lipid droplets. Cellular localization: Endoplasmic reticulum membrane, Peripheral membrane protein. Golgi apparatus, Golgi stack membrane, Peripheral membrane protein. Associated with the endoplasmic reticulum and Golgi stacks, in particular in the juxta-nuclear Golgi region.Synonyms: GTBPB, GTP-binding protein SAR1b, SAR1B, SARA2, SARB

Gene ID: 51128

NCBI Accession: NP_001028675

Pathways: Lipid Metabolism