PRUNE antibody

Catalog No. ABIN954343

Product Details anti-PRUNE Antibody

Target: PRUNE (Prune Exopolyphosphatase (PRUNE))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PRUNE antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody recognizes PRUNE

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Protein A Chromatography

Immunogen: Recombinant protein.

Clone: 1C11

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.2

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PRUNE

Target: PRUNE (Prune Exopolyphosphatase (PRUNE))

Alternative Name: PRUNE (PRUNE Products)

Synonyms: PRUNE antibody, DRES-17 antibody, DRES17 antibody, HTCD37 antibody, 9230112O05Rik antibody, C130058A12 antibody, PRUNEM1 antibody, Prune-M1 antibody, prune exopolyphosphatase antibody, prune exopolyphosphatase 1 antibody, PRUNE1 antibody, Prune1 antibody

Background: PRUNE, the human homologue of the Drosophila gene, is located in 1q21.3, a region highly amplified in human sarcomas, malignant tumours of mesenchymal origin. Human prune (h-prune), a phosphoesterase DHH family appertaining protein, physically interacts with nm23-H1, a metastasis suppressor gene. h-prune is involved in cellular motility and metastasis formation. Metastatic breast cancers were found to overexpress h-prune, h-prune was also found to be highly expressed in colorectal and pancreatic cancers. Hence h-prune is considered useful as a marker for tumor aggressiveness.Synonyms: DRES-17, DRES17, Drosophila-related expressed sequence 17, HTcD37, Protein prune homolog, hPrune

Gene ID: 58497

NCBI Accession: NP_067045

UniProt: Q86TP1