GSAP antibody (C-Term)

Catalog No. ABIN954149

Product Details anti-GSAP Antibody

Target: GSAP (PION) (Pigeon Homolog (PION))

Binding Specificity: AA 536-565, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GSAP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody recognizes Human PION (C-term).

Purification: Affinity Chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 536-565 amino acids from the C-terminal region of human PION

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for GSAP

Target: GSAP (PION) (Pigeon Homolog (PION))

Alternative Name: PION / GSAP (PION Products)

Synonyms: PION antibody, A530088I07Rik antibody, Pion antibody, gamma-secretase activating protein antibody, GSAP antibody, Gsap antibody

Background: Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD, MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1, MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP, MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed 20811458]).Synonyms: Gamma-secretase-activating protein, Protein pigeon homolog

Molecular Weight: 97802 Da

Gene ID: 54103

NCBI Accession: NP_059135