PDE1B antibody (C-Term)

Catalog No. ABIN954063

Product Details anti-PDE1B Antibody

Target: PDE1B (phosphodiesterase 1B, Calmodulin-Dependent (PDE1B))

Binding Specificity: AA 480-508, C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE1B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody recognizes Human and Mouse PDE1B (C-term).

Purification: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 480-508 amino acids from the C-terminal region of Human PDE1B

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PDE1B

Target: PDE1B (phosphodiesterase 1B, Calmodulin-Dependent (PDE1B))

Alternative Name: PDE1B (PDE1B Products)

Synonyms: 63kDa antibody, Pde1b1 antibody, PDE1B1 antibody, PDES1B antibody, Aop2 antibody, phosphodiesterase 1B, Ca2+-calmodulin dependent antibody, phosphodiesterase 1B antibody, Pde1b antibody, PDE1B antibody

Background: Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been classified into several families based on their biochemical properties. Members of the PDE1 family, such as PDE1B, are calmodulin (see MIM 114180)-dependent PDEs (CaM-PDEs) that are stimulated by a calcium-calmodulin complex (Repaske et al., 1992 [PubMed 1326532]).Synonyms: 5'-cyclic nucleotide phosphodiesterase 1B, 63 kDa Cam-PDE, Calcium/calmodulin-dependent 3', Cam-PDE 1B, PDE1B1, PDES1B, Phosphodiesterase 1B, Phosphodiesterase-1B calmodulin-dependent

Molecular Weight: 61380 Da

Gene ID: 5153

NCBI Accession: NP_000915

Pathways: Neurotrophin Signaling Pathway, cAMP Metabolic Process, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma