PCDHGA1 antibody (Middle Region)

Catalog No. ABIN954047

Product Details anti-PCDHGA1 Antibody

Target: PCDHGA1 (Protocadherin gamma A1 (PCDHGA1))

Binding Specificity: AA 294-323, Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCDHGA1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody recognizes Human PCDHGA1 (Center).

Purification: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 294-323 amino acids from the Central region of human PCDHGA1

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PCDHGA1

Target: PCDHGA1 (Protocadherin gamma A1 (PCDHGA1))

Alternative Name: PCDHGA1 (PCDHGA1 Products)

Synonyms: PCDH-GAMMA-A1 antibody, protocadherin gamma subfamily A, 1 antibody, protocadherin gamma-C5 antibody, PCDHGA1 antibody, LOC478038 antibody, Pcdhga1 antibody

Background: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.Synonyms: PCDH-gamma-A1, Protocadherin gamma-A1

Molecular Weight: 90kd

Gene ID: 56114

NCBI Accession: NP_061735