PCDHA5 antibody (Middle Region)

Catalog No. ABIN954033

Product Details anti-PCDHA5 Antibody

Target: PCDHA5 (Protocadherin alpha 5 (PCDHA5))

Binding Specificity: AA 294-323, Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCDHA5 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to PCDHA5.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 294-323 amino acids from the Central region of human PCDHA5

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PCDHA5

Target: PCDHA5 (Protocadherin alpha 5 (PCDHA5))

Alternative Name: PCDHA5 (PCDHA5 Products)

Synonyms: CNR6 antibody, CNRN6 antibody, CNRS6 antibody, CRNR6 antibody, PCDH-ALPHA5 antibody, Cnr6 antibody, Crnr6 antibody, rCNRv05 antibody, PCDHA5 antibody, Pcdha5 antibody, protocadherin alpha 5 antibody, protocadherin alpha-5 antibody, PCDHA5 antibody, Pcdha5 antibody, LOC100738784 antibody, LOC100847156 antibody, LOC100713870 antibody, LOC100629824 antibody

Background: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.Synonyms: CNRS6, PCDH-alpha-5, Protocadherin alpha-5

Molecular Weight: 102048 Da

Gene ID: 56143

NCBI Accession: NP_061731