MRPS12 antibody (Middle Region)

Catalog No. ABIN953516

Product Details anti-MRPS12 Antibody

Target: MRPS12 (Mitochondrial Ribosomal Protein S12 (MRPS12))

Binding Specificity: AA 35-67, Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MRPS12 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody recognizes Human MRPS12 (Center).

Purification: Affinity Chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 35-67 amino acids from the Central region of Human MRPS12 Genename: MRPS12

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for MRPS12

Target: MRPS12 (Mitochondrial Ribosomal Protein S12 (MRPS12))

Alternative Name: MRPS12 (MRPS12 Products)

Synonyms: MPR-S12 antibody, MT-RPS12 antibody, RPMS12 antibody, RPS12 antibody, RPSM12 antibody, AI327385 antibody, Rpms12 antibody, rps12 antibody, CG7925 antibody, Dmel\\CG7925 antibody, EG:BACH59J11.1 antibody, MRP-S12 antibody, MRPS12 antibody, S12 antibody, Tko antibody, l(1)3Ab antibody, l(1)tko antibody, mRpS12 antibody, mt-rps12 antibody, MGC64304 antibody, GB10531 antibody, mitochondrial ribosomal protein S12 antibody, technical knockout antibody, mitochondrial ribosomal protein S12 L homeolog antibody, 40S ribosomal protein S12, mitochondrial antibody, putative mitochondrial 37S ribosomal protein MRPS12 antibody, fragile site, aphidicolin type, common, fra(6)(p22.2) antibody, MRPS12 antibody, Mrps12 antibody, tko antibody, mrps12.L antibody, LOC409723 antibody, mRpS12 antibody, mrps12 antibody, CAALFM_C106070WA antibody, mrpS12 antibody, FRA6C antibody

Background: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75 % protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5' UTR have been found for this gene, all three variants encode the same proteinSynonyms: 28S ribosomal protein S12, MRP-S12, MT-RPS12, RPMS12, RPSM12, S12mt, mitochondrial

Gene ID: 6183

NCBI Accession: NP_066930

Pathways: Sensory Perception of Sound