MNDA antibody (N-Term)

Catalog No. ABIN953470

Product Details anti-MNDA Antibody

Target: MNDA (Myeloid Cell Nuclear Differentiation Antigen (MNDA))

Binding Specificity: AA 33-61, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MNDA antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody recognizes Human MNDA (N-term).

Purification: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 33-61 amino acids from the N-terminal region of human MNDA

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for MNDA

Target: MNDA (Myeloid Cell Nuclear Differentiation Antigen (MNDA))

Alternative Name: MNDA (MNDA Products)

Synonyms: PYHIN3 antibody, A730048F03 antibody, Ifi205b antibody, myeloid cell nuclear differentiation antigen antibody, interferon activated gene 211 antibody, MNDA antibody, Ifi211 antibody

Background: The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons.Synonyms: Myeloid cell nuclear differentiation antigen

Molecular Weight: 45836 Da

Gene ID: 4332

NCBI Accession: NP_002423