INHBB antibody (C-Term)

Catalog No. ABIN952903

Product Details anti-INHBB Antibody

Target: INHBB (Inhibin, beta B (INHBB))

Binding Specificity: AA 376-404, C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This INHBB antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody recognizes Human and Mouse INHBB (C-term).

Characteristics: Purified Ig fraction

Purification: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 376-404 amino acids from the C-terminal region of human INHBB

Isotype: Ig Fraction

Application Details

Application Notes: Suggested dilutions:
ELISA: 1/1000.
Western Blot: 1/100-1/500.
Immunohistochemistry on Paraffin Sections: 1/10-1/50.

Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

References for anti-INHBB antibody (ABIN952903)

Zhong, Pons, Poirier, Jiang, Liu, Sandusky, Shahda, Nakeeb, Schmidt, House, Ceppa, Zyromski, Liu, Jiang, Couch, Koniaris, Zimmers: "The systemic activin response to pancreatic cancer: implications for effective cancer cachexia therapy." in: Journal of cachexia, sarcopenia and muscle, Vol. 10, Issue 5, pp. 1083-1101, (2020) (PubMed).

Target Details for INHBB

Target: INHBB (Inhibin, beta B (INHBB))

Alternative Name: Inhibin beta B Chain (INHBB) (INHBB Products)

Background: The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.Synonyms: Activin B, Activin beta-B chain

Molecular Weight: 45122 Da

Gene ID: 3625

NCBI Accession: NP_002184

UniProt: P09529

Pathways: Peptide Hormone Metabolism, Hormone Activity, Negative Regulation of Hormone Secretion