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FBXW7 antibody (AA 599-708)

FBXW7 Reactivity: Human WB, IHC (p), EIA Host: Mouse Monoclonal 3D1 unconjugated
Catalog No. ABIN952295
  • Target See all FBXW7 Antibodies
    FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))
    Binding Specificity
    • 15
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 599-708
    Reactivity
    • 63
    • 35
    • 32
    • 16
    • 15
    • 14
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 52
    • 12
    Mouse
    Clonality
    • 55
    • 9
    Monoclonal
    Conjugate
    • 33
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This FBXW7 antibody is un-conjugated
    Application
    • 54
    • 24
    • 15
    • 13
    • 13
    • 11
    • 5
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    Recognizes Fbxw7
    Cross-Reactivity (Details)
    Species reactivity (tested):Human.
    Purification
    Protein A Chromatography
    Immunogen
    FBXW7 (NP_361014, 599 a.a. ~ 708 a.a) partial recombinant protein with GST tag.
    Clone
    3D1
    Isotype
    IgG2a
    Top Product
    Discover our top product FBXW7 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    PBS, pH 7.2
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))
    Alternative Name
    FBXW7 (FBXW7 Products)
    Synonyms
    cdc4 antibody, AGO antibody, CDC4 antibody, FBW6 antibody, FBW7 antibody, FBX30 antibody, FBXO30 antibody, FBXW6 antibody, SEL-10 antibody, SEL10 antibody, hAgo antibody, hCdc4 antibody, 1110001A17Rik antibody, Cdc4 antibody, Fbw7 antibody, Fbwd6 antibody, Fbx30 antibody, Fbxo30 antibody, Fbxw6 antibody, F-box and WD repeat domain containing 7 antibody, F-box and WD-40 domain protein 7 antibody, Fbxw7 antibody, FBXW7 antibody, fbxw7 antibody
    Background
    Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.Synonyms: Archipelago homolog, F-box and WD-40 domain-containing protein 7, F-box protein FBX30, F-box/WD repeat-containing protein 7, FBW7, FBX30, SEL-10, SEL10, hAgo, hCDC4
    Gene ID
    55294
    NCBI Accession
    NP_001013433
    UniProt
    Q969H0
    Pathways
    Notch Signaling, EGFR Signaling Pathway
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