Dynamitin antibody (Middle Region)

Catalog No. ABIN952005

Product Details anti-Dynamitin Antibody

Target: Dynamitin (DCTN2) (Dynactin 2 (p50) (DCTN2))

Binding Specificity: AA 191-219, Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Dynamitin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody recognizes Human Dynactin subunit 2 (Center).

Purification: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 191-219 amino acids from the Central region of Human Dynactin subunit 2. Genename: DCTN2

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Dynamitin

Target: Dynamitin (DCTN2) (Dynactin 2 (p50) (DCTN2))

Alternative Name: Dynactin Subunit 2 (DCTN2 Products)

Synonyms: DCTN2 antibody, dctn2 antibody, dctn50 antibody, dynamitin antibody, rbp50 antibody, CG8269 antibody, DMN antibody, Dmel\\CG8269 antibody, P50 antibody, dDyn antibody, dmn antibody, dyna antibody, l(2)k16109 antibody, l(2)k16218 antibody, p50 antibody, p50/Dmn antibody, p50/dynamitin antibody, 2310042E05Rik antibody, C130077D06Rik antibody, C87049 antibody, DCTN-50 antibody, GMP23-48K antibody, RBP50 antibody, DCTN50 antibody, DYNAMITIN antibody, zgc:63867 antibody, dynactin subunit 2 antibody, dynactin subunit 2 S homeolog antibody, Dynactin 2, p50 subunit antibody, dynactin 2 antibody, dynactin 2 (p50) antibody, dynactin subunit 2 L homeolog antibody, DCTN2 antibody, dctn2.S antibody, DCTN2-p50 antibody, dctn2 antibody, Dctn2 antibody, dctn2.L antibody

Background: This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place.Synonyms: 50 kDa dynein-associated polypeptide, DCTN2, DCTN50, Dynactin 2, Dynactin complex 50 kDa subunit, RBP50, p50 dynamitin

Molecular Weight: 44231 Da

Gene ID: 10540

NCBI Accession: NP_006391

Pathways: M Phase, Ribonucleoprotein Complex Subunit Organization