CSDA antibody (Middle Region)

Catalog No. ABIN951934

Product Details anti-CSDA Antibody

Target: CSDA (Cold Shock Domain Protein A (CSDA))

Binding Specificity: AA 151-181, Middle Region

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CSDA antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody recognizes Human and Mouse DNA-binding protein A (Center).

Purification: Affinity Chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 151-181 amino acids from the Central region of Human CSDA. Genename: CSDA

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

References for anti-CSDA antibody (ABIN951934)

Lima, Parreira, Devuyst, Caplanusi, Nkuli, Marien, Van Der Smissen, Alves, Verroust, Christensen, Terzi, Matter, Balda, Pierreux, Courtoy: "ZONAB promotes proliferation and represses differentiation of proximal tubule epithelial cells." in: Journal of the American Society of Nephrology : JASN, Vol. 21, Issue 3, pp. 478-88, (2010) (PubMed).

Gao, Kang, Liao, Ding, Gambotto, Watkins, Liu, Stolz, Yin: "Biochemical isolation and characterization of the tubulovesicular LC3-positive autophagosomal compartment." in: The Journal of biological chemistry, Vol. 285, Issue 2, pp. 1371-83, (2010) (PubMed).

Buchert, Darido, Lagerqvist, Sedello, Cazevieille, Buchholz, Bourgaux, Pannequin, Joubert, Hollande: "The symplekin/ZONAB complex inhibits intestinal cell differentiation by the repression of AML1/Runx1." in: Gastroenterology, Vol. 137, Issue 1, pp. 156-64, 164.e1-3, (2009) (PubMed).

Sharpe Elles, Sykes, Williamson, Uhlenbeck: "A dominant negative mutant of the E. coli RNA helicase DbpA blocks assembly of the 50S ribosomal subunit." in: Nucleic acids research, Vol. 37, Issue 19, pp. 6503-14, (2009) (PubMed).

Wang, Zheng, Che, Wang, Zhao, Wu, Zeng, Pan, He: "Upregulation of human DNA binding protein A (dbpA) in gastric cancer cells." in: Acta pharmacologica Sinica, Vol. 30, Issue 10, pp. 1436-42, (2009) (PubMed).

Hayashi, Kajino, Umeda, Takano, Arakawa, Kudo, Hino: "Somatic mutation and SNP in the promoter of dbpA and human hepatocarcinogenesis." in: International journal of oncology, Vol. 21, Issue 4, pp. 847-50, (2002) (PubMed).

Target Details for CSDA

Target: CSDA (Cold Shock Domain Protein A (CSDA))

Alternative Name: DNA-Binding Protein A (CSDA Products)

Background: CSDA binds to the GM-CSF promoter. Seems to act as a repressor. Binds also to full length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity).Synonyms: CSDA, CSDA1, Cold shock domain-containing protein A, DBPA, Single-strand DNA-binding protein NF-GMB, ZONAB

Molecular Weight: 40090 Da

Gene ID: 8531

NCBI Accession: NP_001138898

Pathways: Negative Regulation of intrinsic apoptotic Signaling