CTPS2 antibody (C-Term)

Catalog No. ABIN951729

Product Details anti-CTPS2 Antibody

Target: CTPS2 (CTP Synthase II (CTPS2))

Binding Specificity: AA 449-479, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CTPS2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to CTPS2.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 449-479 amino acids from the C-terminal region of human CTPS2

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CTPS2

Target: CTPS2 (CTP Synthase II (CTPS2))

Alternative Name: CTP Synthase 2 (CTPS2 Products)

Synonyms: A830031M15Rik antibody, AI326475 antibody, Ctpsh antibody, CTP synthase 2 L homeolog antibody, CTP synthase 2 antibody, cytidine 5'-triphosphate synthase 2 antibody, ctps2.L antibody, CTPS2 antibody, ctps2 antibody, Ctps2 antibody

Background: The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Three alternatively spliced transcript variants encoding the same protein have been described for this gene.Synonyms: CTP synthetase 2, CTPS2, UTP-ammonia ligase 2

Molecular Weight: 65678 Da

Gene ID: 56474

NCBI Accession: NP_001137474

Pathways: Ribonucleoside Biosynthetic Process