CPT1C antibody (C-Term)

Catalog No. ABIN951689

Product Details anti-CPT1C Antibody

Target: CPT1C (Carnitine Palmitoyltransferase 1C (CPT1C))

Binding Specificity: AA 759-790, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CPT1C antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to CPT1C.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 759-790 amino acids from the C-terminal region of human CPT1C

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CPT1C

Target: CPT1C (Carnitine Palmitoyltransferase 1C (CPT1C))

Alternative Name: CPT1C / CPT1-B (CPT1C Products)

Background: The Cpt1 family of proteins are outer mitochondrial membrane proteins that regulate the entry into, and oxidation of fatty acids by, mitochondria. Malonyl-CoA, an intermediate in fatty acid synthesis, has been implicated as a regulatory component of the energy sensing system that feeds into hypothalmic neurons to impart energy homeostasis. Malonyl-CoA levels in the hypothalamus are dynamically regulated by fasting and feeding, altering subsequent feeding behaviour. Cpt1c, the brain-specific carnitine O-palmitoyltransferase 1, is thought to relay information about malonyl-CoA levels in hypothalamic neurons that express orexigenic and anorexigenic neuropeptides that regulate food intake and peripheral energy expenditure. Unlike other Cpt1 proteins, Cpt1c binds Malonyl-CoA but does not catalyse the transfer of the malonyl group from CoA to carnitine.Synonyms: CPT IC, Carnitine O-palmitoyltransferase 1, Carnitine palmitoyltransferase 1C, brain isoform

Molecular Weight: 90989 Da

Gene ID: 126129

NCBI Accession: NP_001129524

Pathways: AMPK Signaling, Monocarboxylic Acid Catabolic Process