Factor XI antibody (Middle Region)

Catalog No. ABIN951607

Product Details anti-Factor XI Antibody

Target: Factor XI (F11) (Coagulation Factor XI (F11))

Binding Specificity: AA 288-315, Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Factor XI antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody recognizes Human Coagulation factor XI (F11) (Center).

Purification: Affinity Chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 288-315 amino acids from the Central region of human F11.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Factor XI

Target: Factor XI (F11) (Coagulation Factor XI (F11))

Abstract: F11 Products

Synonyms: FXI antibody, 1600027G01Rik antibody, AI503996 antibody, Cf11 antibody, LRRGT00086 antibody, coagulation factor XI antibody, F11 antibody, CpipJ_CPIJ000593 antibody, CpipJ_CPIJ001060 antibody, CpipJ_CPIJ002752 antibody, CpipJ_CPIJ003631 antibody, CpipJ_CPIJ004041 antibody, CpipJ_CPIJ004093 antibody

Background: This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq].Synonyms: FX1, PTA, Plasma thromboplastin antecedent

Molecular Weight: 70109 Da

Gene ID: 2160

NCBI Accession: NP_000119