CLASP2 antibody (AA 1005-1034)

Catalog No. ABIN951541

Product Details anti-CLASP2 Antibody

Target: CLASP2 (Cytoplasmic Linker Associated Protein 2 (CLASP2))

Binding Specificity: AA 1005-1034

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLASP2 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Cross-Reactivity (Details): Species reactivity (tested):Human and Mouse.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 1005~1034 amino acids from the Y1019 region of human CLASP2

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CLASP2

Target: CLASP2 (Cytoplasmic Linker Associated Protein 2 (CLASP2))

Alternative Name: CLASP2 (CLASP2 Products)

Synonyms: zgc:77279 antibody, DKFZp459M112 antibody, 1500004F14Rik antibody, 8030404L10Rik antibody, C77448 antibody, CLASP2beta antibody, mKIAA0627 antibody, cytoplasmic linker associated protein 2 antibody, CLIP associating protein 2 antibody, clasp2 antibody, CLASP2 antibody, Clasp2 antibody

Background: CLASP2 is microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.Synonyms: CLIP-associating protein 2, Cytoplasmic linker-associated protein 2, KIAA0627, Protein Orbit homolog 2, hOrbit2

Molecular Weight: 141133 Da

Gene ID: 9606

Pathways: Microtubule Dynamics, Maintenance of Protein Location