CIRBP antibody (C-Term)

Catalog No. ABIN951531

Product Details anti-CIRBP Antibody

Target: CIRBP (Cold Inducible RNA Binding Protein (CIRBP))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CIRBP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to CIRBP.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide selected from the C-terminal region of human CIRBP

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CIRBP

Target: CIRBP (Cold Inducible RNA Binding Protein (CIRBP))

Alternative Name: CIRBP (CIRBP Products)

Synonyms: CIRP antibody, Cirp antibody, R74941 antibody, Xcirp antibody, cirbp antibody, cirbp-a antibody, cirbp2 antibody, cirp antibody, cirp1 antibody, cirp2 antibody, xcirp2 antibody, XCIRP antibody, XCIRP-1 antibody, cirbp-b antibody, cirp-1 antibody, APBP-1 antibody, zgc:136559 antibody, CIRBP antibody, A18 hnRNP antibody, cold inducible RNA binding protein antibody, cold-inducible RNA-binding protein antibody, cold inducible RNA binding protein S homeolog antibody, cold inducible RNA binding protein L homeolog antibody, cold inducible RNA binding protein b antibody, CIRBP antibody, EDI_107320 antibody, Cirbp antibody, cirbp.S antibody, cirbp.L antibody, cirbp antibody, cirbpb antibody

Background: CIRBP is cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. It acts as a translational activator and seems to play an essential role in cold-induced suppression of cell proliferation. It binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. This protein acts as a translational repressor (By similarity) and promotes assembly of stress granules (SGs), when overexpressed.Synonyms: A18HNRNP, CIRP, Cold-inducible RNA-binding protein, Glycine-rich RNA-binding protein CIRP

Molecular Weight: 18648 Da

Gene ID: 1153

NCBI Accession: NP_001271

Pathways: Ribonucleoprotein Complex Subunit Organization