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CD11b antibody (N-Term)
ITGAM
Reactivity: Human
FACS, WB, IHC (p), EIA
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-CD11b Antibody
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Target
See all CD11b (ITGAM) Antibodies
CD11b (ITGAM)
(Integrin alpha M (ITGAM))
Binding Specificity
All epitopes for CD11b antibodies
AA 256-286, N-Term
Reactivity
All reactivities for CD11b antibodies
Human
Host
All hosts for CD11b antibodies
Rabbit
Clonality
All clonalities for CD11b antibodies
Polyclonal
Conjugate
All conjugates for CD11b antibodies
This CD11b antibody is un-conjugated
Application
All applications for CD11b antibodies
Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
Specificity
This antibody reacts to CD11b.
Cross-Reactivity (Details)
Species reactivity (tested):Human.
Purification
Affinity chromatography on Protein A
Immunogen
KLH conjugated synthetic peptide between 256-286 amino acids from the N-terminal region of human CD11b
Isotype
Ig Fraction
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
0.25 mg/mL
Buffer
PBS, 0.09 % (W/V) sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for CD11b
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Target
CD11b (ITGAM)
(Integrin alpha M (ITGAM))
Alternative Name
CD11b (ITGAM Products )
Synonyms
CD11b/CD18 antibody, CR3 antibody, CR3A antibody, Cd11b antibody, F730045J24Rik antibody, Ly-40 antibody, MAC1 antibody, Mac-1 antibody, Mac-1a antibody, CD11B antibody, MAC-1 antibody, MAC1A antibody, MO1A antibody, SLEB6 antibody, C3bi antibody, integrin subunit alpha M antibody, integrin alpha M antibody, integrin, alpha M (complement component 3 receptor 3 subunit) antibody, integrin alpha-M antibody, ITGAM antibody, Itgam antibody, LOC100351865 antibody
Background
CD11b is the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles.Synonyms: CD11 antigen-like family member B, CR-3 alpha chain, CR3A, Cell surface glycoprotein MAC-1 subunit alpha, ITGAM, Integrin alpha-M, Leukocyte adhesion receptor MO1, MAC1, Neutrophil adherence receptor
Molecular Weight
127179 Da
Gene ID
3684
NCBI Accession
NP_000623
Pathways
Apoptosis , Activation of Innate immune Response , Toll-Like Receptors Cascades , Activated T Cell Proliferation
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