beta Arrestin 1 antibody (C-Term)

Catalog No. ABIN950521

Product Details anti-beta Arrestin 1 Antibody

Target: beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))

Binding Specificity: AA 343-371, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This beta Arrestin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to Arrestin beta-1.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 343-371 amino acids from the C-terminal region of human ARRB1

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) sodium azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for beta Arrestin 1

Target: beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))

Alternative Name: Arrestin beta-1 / ARRB1 (ARRB1 Products)

Synonyms: arrb1 antibody, MGC83787 antibody, arb1 antibody, arr1 antibody, barr1 antibody, betaarr1 antibody, 1200006I17Rik antibody, AW208571 antibody, G430100A01Rik antibody, ARB1 antibody, ARR1 antibody, BARRES antibody, arrestin beta 1 antibody, arrestin, beta 1 antibody, arrestin beta 1 L homeolog antibody, beta-arrestin 1 antibody, putative beta-arrestin 1 antibody, ARRB1 antibody, arrb1 antibody, arrb1.L antibody, CpipJ_CPIJ016988 antibody, CpipJ_CPIJ017114 antibody, Smp_122900 antibody, Smp_126080 antibody, Smp_176980 antibody, Smp_152290 antibody, Arrb1 antibody

Background: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known.Synonyms: ARR1, Beta-arrestin-1

Gene ID: 408

NCBI Accession: NP_004032

Pathways: Positive Regulation of Peptide Hormone Secretion, Nuclear Hormone Receptor Binding, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction