HLA-DR1 antibody
HLA-DR1
Reactivity: Human
FACS, ELISA, WB
Host: Mouse
Monoclonal
MEM-267
unconjugated
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- Target See all HLA-DR1 products
- HLA-DR1 (MHC Class II HLA-DR1 (HLA-DR1))
- Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This HLA-DR1 antibody is un-conjugated
- Application
- Flow Cytometry (FACS), ELISA, Western Blotting (WB)
- Specificity
- The antibody MEM-267 specifically binds extracellularly to the empty but not peptide-loaded form of HLA-DR1. DR is the isotypes of human MHC Class II molecules expressed on antigen-presenting cells (APC, dendritic cells, B lymphocytes, monocytes, macrophages).
- Cross-Reactivity (Details)
- Human
- Purification
- Purified by protein-A affinity chromatography.
- Purity
- > 95 % (by SDS-PAGE)
- Immunogen
- Purified, insoluble DR1 beta chain (DRB1*0101) expressed in E. coli inclusion bodies.
- Clone
- MEM-267
- Isotype
- IgG2b
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anti-MHC Class II HLA-DR1 (HLA-DR1) antibody (PE)
HLA-DR1 Reactivity: Human FACS Host: Mouse Monoclonal MEM-267 PE
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- Application Notes
- Flow cytometry: The antibody MEM-267 stains immature dendritic cells that express empty cell surface MHC molecules, but not cells that express predominantly peptide loaded forms.
- Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Do not freeze.
- Storage
- 4 °C
- Storage Comment
- Store at 2-8°C. Do not freeze.
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- Target
- HLA-DR1 (MHC Class II HLA-DR1 (HLA-DR1))
- Alternative Name
- HLA-DR1 (HLA-DR1 Products)
- Background
- HLA-DR1 belongs to the HLA class II beta chain paralogues. The MHC Class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. MHC Class II molecules are expressed in antigen presenting cells (APC). The beta chain is approximately 26-28 kDa. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.
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