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IGF2R antibody

IGF2R Reactivity: Human, Non-Human Primate WB, FACS, IP Host: Mouse Monoclonal MEM-238 unconjugated
Catalog No. ABIN94039
  • Target See all IGF2R Antibodies
    IGF2R (Insulin-Like Growth Factor 2 Receptor (IGF2R))
    Reactivity
    • 88
    • 36
    • 19
    • 8
    • 4
    • 3
    • 2
    • 1
    • 1
    Human, Non-Human Primate
    Host
    • 68
    • 22
    Mouse
    Clonality
    • 67
    • 23
    Monoclonal
    Conjugate
    • 46
    • 6
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IGF2R antibody is un-conjugated
    Application
    • 34
    • 32
    • 28
    • 23
    • 14
    • 13
    • 13
    • 11
    • 8
    • 5
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP)
    Specificity
    The antibody MEM-238 recognizes an extracellular epitope between amino acids 192-697 of CD222 (IGF2 receptor), a ubiquitously expressed 250 kDa multifunctional type I transmembrane protein. The majority of CD222 is found in the late endosomal/prelysosomal compartment, 5-10 % in the plasma membrane and the truncated (220 kDa) form of CD222 is present in human and bovine serum.
    Cross-Reactivity (Details)
    Human, Non-Human Primates
    Purification
    Purified by protein-A affinity chromatography.
    Purity
    > 95 % (by SDS-PAGE)
    Immunogen
    Recombinant Vaccinia virus encoding CD222.
    Clone
    MEM-238
    Isotype
    IgG1
  • Application Notes
    Flow cytometry: Extracellular and intracellular staining. Recommended dilution: 2-6 μg/mL.
    Western blotting: Non-reducing conditions.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Do not freeze.
    Storage
    4 °C
    Storage Comment
    Store at 2-8°C. Do not freeze.
  • Schatzlmaier, Supper, Göschl, Zwirzitz, Eckerstorfer, Ellmeier, Huppa, Stockinger: "Rapid multiplex analysis of lipid raft components with single-cell resolution." in: Science signaling, Vol. 8, Issue 395, pp. rs11, (2015) (PubMed).

    Leksa, Godár, Cebecauer, Hilgert, Breuss, Weidle, Horejsí, Binder, Stockinger: "The N terminus of mannose 6-phosphate/insulin-like growth factor 2 receptor in regulation of fibrinolysis and cell migration." in: The Journal of biological chemistry, Vol. 277, Issue 43, pp. 40575-82, (2002) (PubMed).

  • Target
    IGF2R (Insulin-Like Growth Factor 2 Receptor (IGF2R))
    Alternative Name
    CD222 (IGF2R Products)
    Synonyms
    CD222 antibody, CIMPR antibody, M6P-R antibody, MPR1 antibody, MPRI antibody, AI661837 antibody, CI-MPR antibody, M6P/IGF2R antibody, Mpr300 antibody, mpri antibody, cd222 antibody, cimpr antibody, m6p-r antibody, insulin like growth factor 2 receptor antibody, insulin-like growth factor 2 receptor antibody, IGF2R antibody, Igf2r antibody, igf2r antibody
    Background
    Insulin like growth factor 2 receptorprovided,CD222 (CIMPR, cation-independent mannose 6-phosphate receptor, IGF2 receptor) is a ubiquitously expressed 250 kDa transmembrane protein. No more than 10 % of CD222 is present on the cell surface where it serves as a multifunctional receptor. Intracellular (major) fraction of CD222 is involved in transport of newly synthesized lysosomal enzymes modified by mannose 6-phosphate from Golgi apparatus to lysosomes. The cell surface CD222 binds and internalizes exogeneous mannose 6-phosphate-containing ligands. Importantly, CD222 is crutial for internalization and degradation of insulin-like growth factor 2, thus controling cell growth. CD222 also complexes CD87 (urokinase-type plasminogen-activator receptor), plasminogen and latent TGF-beta, last but not least CD222 serves as a receptor for heparanase and even for Listeria.,IGF2R, MPR1, CIMPR, MPR300, M6P-R
    Gene ID
    3482
    UniProt
    P11717
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