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MLL/KMT2A antibody (AA 3751-3968)
MLL
Reactivity: Human
WB, IHC, ELISA
Host: Mouse
Monoclonal
10F8D7
unconjugated
Product Details anti-MLL/KMT2A Antibody
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Target
See all MLL/KMT2A (MLL) Antibodies
MLL/KMT2A (MLL)
(Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))
Binding Specificity
All epitopes for MLL/KMT2A antibodies
AA 3751-3968
Reactivity
All reactivities for MLL/KMT2A antibodies
Human
Host
All hosts for MLL/KMT2A antibodies
Mouse
Clonality
All clonalities for MLL/KMT2A antibodies
Monoclonal
Conjugate
All conjugates for MLL/KMT2A antibodies
This MLL/KMT2A antibody is un-conjugated
Application
All applications for MLL/KMT2A antibodies
Western Blotting (WB), Immunohistochemistry (IHC), ELISA
Immunogen
MLL antibody was raised in Mouse using a purified recombinant fragment of MLL(aa3751-3968) expressed in E. coli as the immunogen.
Clone
10F8D7
Isotype
IgG1
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Alternatives
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Application Details
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Application Notes
ELISA: 1:10,000, IHC: 1:200-1:1000, WB: 1:500-1:2000 Optimal conditions should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
Lot specific
Buffer
Supplied as a liquid in ascitic fluid containing 0.03 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Handling Advice
Avoid repeated freeze/thaw cycles. Dilute only prior to immediate use.
Storage
4 °C/-20 °C
Storage Comment
Store at 4 °C for short term storage. Store at -20 °C for long term storage.
Target Details for MLL/KMT2A
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Target
MLL/KMT2A (MLL)
(Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))
Alternative Name
MLL (MLL Products )
Synonyms
ALL-1 antibody, CXXC7 antibody, HRX antibody, HTRX1 antibody, MLL antibody, MLL/GAS7 antibody, MLL1A antibody, TET1-MLL antibody, TRX1 antibody, WDSTS antibody, 6430520K01 antibody, All1 antibody, Cxxc7 antibody, Mll antibody, Mll1 antibody, mKIAA4050 antibody, lysine methyltransferase 2A antibody, lysine (K)-specific methyltransferase 2A antibody, KMT2A antibody, Kmt2a antibody
Background
MLL contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Synonyms: Monoclonal MLL antibody, Anti-MLL antibody, Myeloid/lymphoid leukemia antibody, ALL-1 antibody, ALL 1 antibody, HRX antibody, Lysine N-methyltransferase 2A antibody, Trithorax-like protein antibody, Zinc finger protein HRX antibody.
Pathways
Warburg Effect
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