RHOB antibody

Catalog No. ABIN931074

Product Details anti-RHOB Antibody

Target: RHOB (Ras Homolog Gene Family, Member B (RHOB))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RHOB antibody is un-conjugated

Application: Dot Blot (DB)

Cross-Reactivity: Human

Cross-Reactivity (Details): Other species not studied.

Purification: Protein G affinity chromatography

Immunogen: RHOB antibody was raised in mouse using recombinant Human Ras Homolog Gene Family, Member B (Rhob)

Clone: 2916C2a

Isotype: IgG1

Application Details

Application Notes: Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: Lot specific

Buffer: RHOB antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1 % bovine serum albumin (BSA) and 0.05 % sodium azide (NaN3 ).

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2-8 °C for up to one year. We recommend long term storage at -20 °C.

Target Details for RHOB

Target: RHOB (Ras Homolog Gene Family, Member B (RHOB))

Alternative Name: RHOB (RHOB Products)

Synonyms: ARH6 antibody, ARHB antibody, MST081 antibody, MSTP081 antibody, RHOH6 antibody, AA017882 antibody, Arh6 antibody, Arhb antibody, RHO antibody, arha antibody, rhoa antibody, wu:fj42e08 antibody, zgc:92206 antibody, rhob antibody, xrhob antibody, ras homolog family member B antibody, ras homolog gene family, member Ab antibody, ras homolog family member B S homeolog antibody, RHOB antibody, Rhob antibody, rhoab antibody, rhob.S antibody

Background: RHOB mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Synonyms: Monoclonal RHOB antibody, Anti-RHOB antibody, Ras homolog gene family member B antibody, ARH6 antibody, ARHB antibody, RHOH6 antibody, MST081 antibody, MSTP081 antibody.