CARD8 antibody

Catalog No. ABIN930979

Product Details anti-CARD8 Antibody

Target: CARD8 (Caspase Recruitment Domain Family, Member 8 (CARD8))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CARD8 antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunoprecipitation (IP), Flow Cytometry (FACS), Dot Blot (DB)

Cross-Reactivity: Human

Cross-Reactivity (Details): Other species not studied.

Purification: Protein G affinity chromatography

Immunogen: CARD8 antibody was raised in mouse using recombinant Human Caspase Recruitment Domain Family, Member 8 (Card8)

Clone: 2108C2a

Isotype: IgG1

Application Details

Application Notes: WB: 0.2-2 µg/mL, IP: 100-500 µg/sample, FC: 0.5-2 µg/sample, ICC: 2-100 µg/mL
Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: Lot specific

Buffer: CARD8 antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1 % bovine serum albumin (BSA) and 0.05 % sodium azide (NaN3 ).

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2-8 °C for up to one year. We recommend long term storage at -20 °C.

Target Details for CARD8

Target: CARD8 (Caspase Recruitment Domain Family, Member 8 (CARD8))

Alternative Name: CARD8 (CARD8 Products)

Synonyms: CARD8 antibody, CARDINAL antibody, DACAR antibody, DAKAR antibody, NDPP antibody, NDPP1 antibody, TUCAN antibody, caspase recruitment domain family, member 8 antibody, caspase recruitment domain-containing protein 8 antibody, caspase recruitment domain family member 8 antibody, CARD8 antibody, LOC718594 antibody

Background: The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. Synonyms: Monoclonal CARD8 antibody, Anti-CARD8 antibody, Caspase recruitment domain family antibody, DACAR antibody, NDPP1 antibody, TUCAN antibody, CARDINAL antibody, KIAA0955 antibody,MGC57162 antibody, DKFZp779L0366 antibody.

Pathways: Positive Regulation of Endopeptidase Activity