CNTF Receptor alpha antibody (C-Term)

Catalog No. ABIN929419

Product Details anti-CNTF Receptor alpha Antibody

Target: CNTF Receptor alpha (CNTFR) (Ciliary Neurotrophic Factor Receptor (CNTFR))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CNTF Receptor alpha antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Purified

Immunogen: CNTFR antibody was raised in rabbit using the C terminal of CNTFR as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

CNTFR Blocking Peptide, catalog no. 33R-1094, is also available for use as a blocking control in assays to test for specificity of this CNTFR antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for CNTF Receptor alpha

Target: CNTF Receptor alpha (CNTFR) (Ciliary Neurotrophic Factor Receptor (CNTFR))

Alternative Name: CNTFR (CNTFR Products)

Synonyms: CNTFR-alpha antibody, CNTFRALPHA antibody, Cntfralpha antibody, cb549 antibody, fj33e02 antibody, sb:cb549 antibody, wu:fj33e02 antibody, si:bz76a6.1 antibody, si:dz248f2.1 antibody, si:rp71-76a6.1 antibody, ciliary neurotrophic factor receptor antibody, ciliary neurotrophic factor receptor L homeolog antibody, CNTFR antibody, cntfr.L antibody, Cntfr antibody, cntfr antibody

Background: This gene encodes a hematopoeitin/interferon-class receptor belonging to the cytokine superfamily of receptors. The encoded gene product represents the CNTF-specific alpha subunit of a heterotrimer forming the CNTF receptor complex, which also includes LIFR and gp130. The receptor is attached to the membrane by a glycosyl-phosphatidylinositol linkage and contains an immunoglobulin-like C2-type domain and a fibronectin type-III domain. Signal transduction requires that CNTF bind first to this alpha component, which permits the recruitment of gp130 and LIFR beta to form the tripartite receptor complex. Signal transduction stimulates gene expression, cell survival or differentiation in a variety of neuronal cell types. Synonyms: Polyclonal CNTFR antibody, Anti-CNTFR antibody, ciliary neurotrophic factor receptor antibody, MGC1774 antibody.

Pathways: JAK-STAT Signaling, Feeding Behaviour