FE65 antibody (N-Term)
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- Target See all FE65 (APBB1) Antibodies
- FE65 (APBB1) (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))
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Binding Specificity
- N-Term
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Reactivity
- Mouse, Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This FE65 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Cross-Reactivity
- Mouse (Murine)
- Purification
- Purified
- Immunogen
- Apbb1 antibody was raised in rabbit using the N terminal of Apbb1 as the immunogen
- Top Product
- Discover our top product APBB1 Primary Antibody
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- Application Notes
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WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator. - Comment
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Apbb1 Blocking Peptide, catalog no. 33R-1963, is also available for use as a blocking control in assays to test for specificity of this Apbb1 antibody
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Concentration
- Lot specific
- Buffer
- Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store at 4 °C, following reconstitution, aliquot and store at -20 °C.
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- Target
- FE65 (APBB1) (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))
- Alternative Name
- Apbb1 (APBB1 Products)
- Synonyms
- FE65 antibody, MGC:9072 antibody, RIR antibody, apbb1 antibody, MGC80654 antibody, Fe65 antibody, Rir antibody, amyloid beta precursor protein binding family B member 1 antibody, amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) L homeolog antibody, amyloid beta (A4) precursor protein-binding, family B, member 1 antibody, APBB1 antibody, apbb1.L antibody, Apbb1 antibody
- Background
- Apbb1 is an adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain.Apbb1 plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. Apbb1 may act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Synonyms: Polyclonal Apbb1 antibody, Anti-Apbb1 antibody, amyloid beta, A4 precursor protein-binding, family B, member 1 antibody, Fe65 antibody, Rir antibody.
- Pathways
- Positive Regulation of Response to DNA Damage Stimulus
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