MBNL2 antibody (Middle Region)

Catalog No. ABIN928546

Product Details anti-MBNL2 Antibody

Target: MBNL2 (Muscleblind-Like 2 (MBNL2))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Zebrafish (Danio rerio), Chicken

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MBNL2 antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Mouse (Murine), Rat (Rattus), Dog (Canine), Chicken, Cow (Bovine), Zebrafish (Brachydanio rerio)

Purification: Purified

Immunogen: MBNL2 antibody was raised in rabbit using the middle region of MBNL2 as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

MBNL2 Blocking Peptide, catalog no. 33R-2607, is also available for use as a blocking control in assays to test for specificity of this MBNL2 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for MBNL2

Target: MBNL2 (Muscleblind-Like 2 (MBNL2))

Alternative Name: MBNL2 (MBNL2 Products)

Synonyms: 1110002M11Rik antibody, AI047808 antibody, AI837313 antibody, AI849185 antibody, AL118326 antibody, MBLL antibody, R75232 antibody, mKIAA4072 antibody, wu:fj89c04 antibody, MBLL39 antibody, PRO2032 antibody, muscleblind like splicing factor 2 antibody, muscleblind-like splicing regulator 2 antibody, muscleblind like splicing regulator 2 antibody, Mbnl2 antibody, mbnl2 antibody, MBNL2 antibody

Background: MBNL2 is a C3H-type zinc finger protein, which is similar to the Drosophila melanogaster muscleblind B protein.MBNL2 is a RNA-binding protein that binds to 5'ACACCC-3' core sequence. It binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. MBNL2 seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm. It may play a role in myotonic dystrophy pathophysiology (DM). Synonyms: Polyclonal MBNL2 antibody, Anti-MBNL2 antibody, muscleblind-like 2, Drosophila antibody, DKFZp781H1296 antibody, MBLL antibody, MBLL39 antibody, MGC120625 antibody, MGC120626 antibody, MGC120628 antibody, PRO2032 antibody.