PYHIN1 antibody (N-Term)

Catalog No. ABIN928476

Product Details anti-PYHIN1 Antibody

Target: PYHIN1 (Pyrin and HIN Domain Family, Member 1 (PYHIN1))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Cow, Dog, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PYHIN1 antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Mouse (Murine), Rat (Rattus), Cow (Bovine), Dog (Canine)

Purification: Purified

Immunogen: PYHIN1 antibody was raised in rabbit using the N terminal of PYHIN1 as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

PYHIN1 Blocking Peptide, catalog no. 33R-1404, is also available for use as a blocking control in assays to test for specificity of this PYHIN1 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for PYHIN1

Target: PYHIN1 (Pyrin and HIN Domain Family, Member 1 (PYHIN1))

Alternative Name: PYHIN1 (PYHIN1 Products)

Synonyms: IFIX antibody, RP11-520H16.1 antibody, 4930422C14 antibody, AI447904 antibody, Ifi209 antibody, Ifix antibody, pyrin and HIN domain family member 1 antibody, interferon activated gene 209 antibody, PYHIN1 antibody, Ifi209 antibody

Background: PYHIN1 belongs to the HIN-200 family. This protein is major mediator of the tumor suppressor activity of IFN in breast cancer cells. It promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization, and HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells. Synonyms: Polyclonal PYHIN1 antibody, Anti-PYHIN1 antibody, pyrin and HIN domain family, member 1 antibody, IFIX antibody, MGC23885 antibody, RP11-520H16.1 antibody.