SIN3B antibody (Middle Region)

Catalog No. ABIN928396

Product Details anti-SIN3B Antibody

Target: SIN3B (SIN3 Transcription Regulator Homolog B (SIN3B))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Cow, Zebrafish (Danio rerio), Xenopus laevis

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIN3B antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Mouse (Murine), Cow (Bovine), Frog, Zebrafish (Brachydanio rerio)

Purification: Purified

Immunogen: SIN3 B antibody was raised in rabbit using the middle region of SIN3 as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

SIN3B Blocking Peptide, catalog no. 33R-5540, is also available for use as a blocking control in assays to test for specificity of this SIN3B antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for SIN3B

Target: SIN3B (SIN3 Transcription Regulator Homolog B (SIN3B))

Alternative Name: SIN3B (SIN3B Products)

Synonyms: fj63d08 antibody, si:dkey-6n6.6 antibody, wu:fj63d08 antibody, 2810430C10Rik antibody, SIN3 transcription regulator family member B antibody, SIN3 transcription regulator family member B S homeolog antibody, transcriptional regulator, SIN3B (yeast) antibody, sin3b antibody, SIN3B antibody, sin3b.S antibody, Sin3b antibody

Background: SIN3B acts as a transcriptional repressor. It interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also, it interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. The gene is also able to form a complex with FOXK1 which represses transcription. Synonyms: Polyclonal SIN3B antibody, Anti-SIN3B antibody, SIN3 homolog B, transcription regulator, yeast antibody, KIAA0700 antibody.