PSMC3IP antibody (C-Term)

Catalog No. ABIN928182

Product Details anti-PSMC3IP Antibody

Target: PSMC3IP (PSMC3 Interacting Protein (PSMC3IP))

Binding Specificity: C-Term

Reactivity: Mouse, Human, Rat, Dog, Cow, Zebrafish (Danio rerio), Xenopus laevis, Chicken

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMC3IP antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Mouse (Murine), Rat (Rattus), Frog, Dog (Canine), Chicken, Cow (Bovine), Zebrafish (Brachydanio rerio)

Purification: Purified

Immunogen: PSMC3 IP antibody was raised in rabbit using the C terminal of PSMC3 P as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

PSMC3IP Blocking Peptide, catalog no. 33R-7037, is also available for use as a blocking control in assays to test for specificity of this PSMC3IP antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for PSMC3IP

Target: PSMC3IP (PSMC3 Interacting Protein (PSMC3IP))

Alternative Name: PSMC3IP (PSMC3IP Products)

Background: PSMC3IP plays an important role in meiotic recombination. It stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. It may inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Synonyms: Polyclonal PSMC3IP antibody, Anti-PSMC3IP antibody, PSMC3 interacting protein antibody, GT198 antibody, HOP2 antibody, TBPIP antibody.