IKZF3 antibody (C-Term)

Catalog No. ABIN927759

Product Details anti-IKZF3 Antibody

Target: IKZF3 (IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Zebrafish (Danio rerio), Chicken, Xenopus laevis

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IKZF3 antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Mouse (Murine), Rat (Rattus), Cow (Bovine), Chicken, Frog, Dog (Canine), Zebrafish (Brachydanio rerio)

Purification: Purified

Immunogen: IKZF3 antibody was raised in rabbit using the C terminal of IKZF3 as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

IKZF3 Blocking Peptide, catalog no. 33R-4872, is also available for use as a blocking control in assays to test for specificity of this IKZF3 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for IKZF3

Target: IKZF3 (IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3))

Alternative Name: IKZF3 (IKZF3 Products)

Background: IKZF3 is a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoetic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described. Synonyms: Polyclonal IKZF3 antibody, Anti-IKZF3 antibody, IKAROS family zinc finger 3, Aiolos antibody, AIOLOS antibody, ZNFN1A3 antibody.