SNF8 antibody (N-Term)

Catalog No. ABIN927326

Product Details anti-SNF8 Antibody

Target: SNF8 (Vacuolar-sorting Protein SNF8 (SNF8))

Binding Specificity: N-Term

Reactivity: Human, Rat, Mouse, Cow, Dog, Zebrafish (Danio rerio), Xenopus laevis, Chicken

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SNF8 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Cross-Reactivity: Mouse (Murine), Rat (Rattus), Frog, Cow (Bovine), Dog (Canine), Chicken, Zebrafish (Brachydanio rerio)

Purification: Purified

Immunogen: EAP30 antibody was raised in rabbit using the N terminal of EAP30 as the immunogen

Application Details

Application Notes: Optimal conditions should be determined by the investigator.

Comment:

EAP30 Blocking Peptide, catalog no. 33R-6102, is also available for use as a blocking control in assays to test for specificity of this EAP30 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for SNF8

Target: SNF8 (Vacuolar-sorting Protein SNF8 (SNF8))

Alternative Name: EAP30 (SNF8 Products)

Synonyms: d11moh34 antibody, vps22 antibody, Dot3 antibody, EAP30 antibody, VPS22 antibody, D11moh34 antibody, RGD1310144 antibody, D11Moh34 antibody, D11MOH34 antibody, zgc:101578 antibody, SNF8, ESCRT-II complex subunit antibody, eap30 subunit of ell complex, putative antibody, EAP30 subunit of ELL complex antibody, SNF8, ESCRT-II complex subunit S homeolog antibody, SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) antibody, snf8 antibody, TA17290 antibody, TVAG_107410 antibody, Bm1_05145 antibody, SNF8 antibody, Snf8 antibody, snf8.S antibody

Background: ELL encodes an RNA polymerase II transcription factor that undergoes frequent translocation in acute myeloid leukemia. In addition to its elongation activity, ELL contains a novel type of RNA polymerase II interaction domain that is capable of repressing polymerase activity in promoter-specific transcription. EAP30 is a subunit of the ELL complex. EAP30 can interact with ELL and derepress ELL's inhibitory activity in vitro.SNF8, VPS25, and VPS36 form ESCRT-II, a complex involved in endocytosis of ubiquitinated membrane proteins. SNF8, VPS25, and VPS36 are also associated in a multiprotein complex with RNA polymerase II elongation factor. Synonyms: Polyclonal EAP30 antibody, Anti-EAP30 antibodyDot3 antibody, EAP30 antibody, VPS22 antibody.